M216
MDL 105,519
≥98% (HPLC), solid
동의어(들):
(E)-4,6-Dichloro-3-(2-phenyl-2-carboxyethenyl)indole-2-carboxylic acid
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모든 사진(1)
크기 선택
보기 변경
5 MG
₩1,242,868
25 MG
₩4,426,009
About This Item
실험식(Hill 표기법):
C18H11Cl2NO4
CAS Number:
Molecular Weight:
376.19
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.32
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
solid
색상
white to off-white
solubility
DMSO: >20 mg/mL
SMILES string
OC(=O)C(=C/c1c([nH]c2cc(Cl)cc(Cl)c12)C(O)=O)\c3ccccc3
InChI
1S/C18H11Cl2NO4/c19-10-6-13(20)15-12(16(18(24)25)21-14(15)7-10)8-11(17(22)23)9-4-2-1-3-5-9/h1-8,21H,(H,22,23)(H,24,25)/b11-8-
InChI key
LPWVUDLZUVBQGP-FLIBITNWSA-N
유전자 정보
human ... GRIN1(2902)
rat ... Grin1(24408)
생화학적/생리학적 작용
MDL 105,519 is a high affinity N-methyl-D-aspartate (NMDA) glutamate receptor antagonist at the glycine site. It inhibits NMDA-dependent responses.[1]
법적 정보
Sold under exclusive license from Hoechst Marion Roussel, Inc.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
B M Baron et al.
European journal of pharmacology, 323(2-3), 181-192 (1997-04-04)
MDL 105,519, (E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H-indole-2-carboxylic acid, is a potent and selective inhibitor of [3H]glycine binding to the NMDA receptor. MDL 105,519 inhibits NMDA (N-methyl-D-aspartate)-dependent responses including elevations of [3H]N-[1,(2-thienyl)cyclohexyl]-piperidine ([3H]TCP) binding in brain membranes, cyclic GMP accumulation in brain slices, and
Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist.
Baron BM
European Journal of Pharmacology, 323(2-3), 181-192 (1997)
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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