L6920
LFM-A13
≥98% (HPLC), powder
동의어(들):
α-Cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide, (2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide; a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide
로그인조직 및 계약 가격 보기
크기 선택
5 MG
₩166,460
모든 사진(1)
크기 선택
보기 변경
5 MG
₩166,460
About This Item
실험식(Hill 표기법):
C11H8Br2N2O2
CAS Number:
Molecular Weight:
360.00
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
양식
powder
색상
white to tan
solubility
DMSO: ≥19 mg/mL
저장 온도
2-8°C
SMILES string
C\C(O)=C(/C#N)C(=O)Nc1cc(Br)ccc1Br
InChI
1S/C11H8Br2N2O2/c1-6(16)8(5-14)11(17)15-10-4-7(12)2-3-9(10)13/h2-4,16H,1H3,(H,15,17)/b8-6-
InChI key
UVSVTDVJQAJIFG-VURMDHGXSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
생화학적/생리학적 작용
LFM-A13 is a potent and selective inhibitor of Bruton′s tyrosine kinase (BTK)
LFM-A13 is an inhibitor of the nonreceptor tyrosine kinase Bruton′s tyrosine kinase (Btk), a new molecular target for treatment of B-cell lymphoma and autoimmune disorders. LFMA13 inhibited recombinant BTK with an IC50 value of 2.5microM with 100-fold lower inhibitory activity against a number of other protein kinases including JAK1, JAK2, EGFR, IRK, IKK, and CDK1, 2 and 3, as well as several other related kinases
특징 및 장점
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Issan Yee San Tam et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 66(1), 25-37 (2016-09-16)
The aim of this study was to develop a novel protocol for generating large populations of fully mature and functional human mast cells (HMC) from CD34 CD34 We have developed a novel protocol that can generate large homogenous populations of
Sandra Olsson et al.
Journal of inflammation (London, England), 3, 8-8 (2006-05-06)
Yeast and bacteria elicit arachidonate release in macrophages, leading to the formation of leukotrienes and prostaglandins, important mediators of inflammation. Receptors recognising various microbes have been identified, but the signalling pathways are not entirely understood. Cytosolic phospholipase A2 is a
Wei Zhang et al.
BioMed research international, 2020, 3152043-3152043 (2020-07-21)
Tec kinase is an important mediator in inflammatory immune response that enhances the activity of neutrophils and macrophages. However, information on its function in lipopolysaccharide- (LPS-) induced acute kidney injury (AKI) is limited. This study is aimed at determining whether
Fei Wang et al.
Oncotarget, 8(21), 34099-34110 (2017-04-19)
Tec kinase, a prototypical member of the Tec tyrosine kinases family, was shown to mainly govern lymphocyte proliferation. In the present study, we investigated the role of Tec kinase in acute inflammatory response in lipopolysaccharide (LPS) challenge. First, we demonstrate
Yuanyuan Li et al.
Oncotarget, 8(30), 49238-49252 (2017-05-18)
Bone marrow X-linked kinase (BMX, also known as Etk) has been reported to be involved in cell proliferation, differentiation, apoptosis, migration and invasion in several types of tumors, but its role in cervical carcinoma remains poorly understood. In this study
문서
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
관련 콘텐츠
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활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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