추천 제품
일반 설명
Monoclonal anti-Human Haptoglobin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Haptoglobin (Hp) is a serum α 2-glycoprotein that exists as a tetramer, composed of two smaller identical α chains and two larger identical β chains. The α-chains are linked to each other by a disulfide bond and each β-chain is similarly linked to an α-chain. Plasma haptoglobin is structurally similar to serum immunoglobulins. Haptoglobin is found in normal plasma at a concentration of 0.3-1.9 mg/ml and accounts for 0.4-2.6% of the total plasma proteins. It is also one of the groups of plasma proteins known as acute phase reactants.
특이성
The antibody is specific for the 3 major haplotypes of human haptoglobin (Types 1-1, 2-1 and 2-2). It does not cross-react with human IgG, transferrin, C-reactive protein, α1-acid glycoprotein, albumin or hemoglobin using ELISA or immunoblotting methods. The antibody recognizes human haptoglobin as purified antigen, in human serum, or when complexed with human hemoglobin in a native or denatured, but non-reduced state.
애플리케이션
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Monoclonal Anti-Haptoglobin antibody produced in mouse has been used in enzyme-linked immunosorbent assay (ELISA) to determine plasma haptoglobin (Hp) levels and to probe duplicate dot blot strips for dot blot assay. It has been used in affinity purification of human high-density lipoprotein (HDL) to obtain trypanosome lytic factor (TLF) and also to prepare an affinity resin.
생화학적/생리학적 작용
The most characteristic property of haptoglobin is its ability to form stable complexes with extra-corpuscular-free native hemoglobin that has been released during hemolysis and is thus thought to prevent iron loss through urinary excretion and to also prevent renal damage from the hemoglobin. In addition, the native form or normal plasma haptoglobin has been shown to exhibit a broad spectrum of immunosuppressive effects in the immune system. Measurement of haptoglobin levels may therefore be used to monitor the progress of inflammatory reactions and assess the efficiency of test drugs.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Robert S Bresalier et al.
Gastroenterology, 127(3), 741-748 (2004-09-14)
Galectin-3 is a beta-galactoside-binding protein implicated in tumor progression and metastasis of colorectal cancers. To determine whether circulating galectin-3 ligands are related to the presence of colon cancer, we sought to identify and quantify ligands in serum that bind to
Association of haptoglobin levels with age, parasite density, and haptoglobin genotype in a malaria-endemic area of Gabon
Fowkes FJI, et al.
The American Journal of Tropical Medicine and Hygiene, 74(1), 26-30 (2006)
Plasma proteomic profile of sulfur mustard exposed lung diseases patients using 2-dimensional gel electrophoresis
Mehrani H, et al.
Clinical Proteomics, 8(1), 2-2 (2010)
Identification and purification of a hemoglobin-binding outer membrane protein from Neisseria gonorrhoeae.
Chen CJ, et al.
Infection and Immunity, 64(12), 5008-5014 (1996)
A Zauberman et al.
The Journal of biological chemistry, 276(27), 24719-24725 (2001-05-02)
Activin A, a member of the transforming growth factor beta (TGFbeta) superfamily, blocks interleukin (IL)-6 biological functions. The molecular basis of the influence of this TGFbeta signaling on the IL-6 receptor triggered cascade is unknown. We studied IL-6-induced secretion of
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
