모든 사진(1)
About This Item
실험식(Hill 표기법):
C35H52O4
CAS Number:
Molecular Weight:
536.78
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥85% (HPLC)
형태
solution
저장 온도
−20°C
SMILES string
CC(C)C(=O)[C@@]12C(O)=C(C\C=C(\C)C)C(=O)[C@@](C\C=C(/C)C)(C[C@H](C\C=C(\C)C)[C@@]1(C)CC\C=C(\C)C)C2=O
InChI
1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,38H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1
InChI key
IWBJJCOKGLUQIZ-HQKKAZOISA-N
일반 설명
Hyperforin is a phloroglucinol component of St. John′s wort and a pregnane X receptor ligand.
애플리케이션
Hyperforin may be used:
- as a reference standard for calibration curve generation in high-perfornamce liquid chromatography (HPLC) analysis
- to test its cytotoxic effect and apoptosis induction in mouse embryonic cells
- as a pregnane X receptor (PXR) in porcine brain capillary endothelial cells for transport assay
생화학적/생리학적 작용
Hyperforin is an active antidepressant and an inhibitor of cytochrome P450 3A4 (CYP3A). It elicits antioxidant and antibacterial activity. Hyperforin is also embryotoxic and inhibits tumor proliferation. It effectively inhibits dopamine, serotonin and norepinephrine.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
표적 기관
Eyes
Storage Class Code
3 - Flammable liquids
WGK
WGK 2
Flash Point (°F)
49.5 °F - closed cup
Flash Point (°C)
9.7 °C - closed cup
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Martina C Meinke et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(2), 346-350 (2012-03-21)
Hyperforin, a major constituent of St. John's Wort (Hypericum perforatum, HP), provides anti-inflammatory, anti-tumor, and anti-bacterial properties. Previous studies have shown anti-oxidative properties of St. John's Wort extracts; however, its free radical scavenging activity in skin cells or skin has
Rajanikanth Madabushi et al.
European journal of clinical pharmacology, 62(3), 225-233 (2006-02-16)
Recently, interactions of herbal medicines with synthetic drugs came into focus of particular interest. In the past 3 years, more than 50 papers were published regarding interactions between St. John's wort (Hypericum perforatum L.; SJW) and prescription drugs. Co-medication with
Induction and inhibition of cytochromes P450 by the St. John's wort constituent hyperforin in human hepatocyte cultures
Komoroski BJ, et al.
Drug Metabolism and Disposition, 32(5), 512-518 (2004)
Determination of hypericin and hyperforin content in selected Jordanian Hypericum species
Tawaha K, et al.
Industrial Crops and Products, 32(3), 241-245 (2010)
L B Moore et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(13), 7500-7502 (2000-06-15)
St. John's wort (Hypericum perforatum) is an herbal remedy used widely for the treatment of depression. Recent clinical studies demonstrate that hypericum extracts increase the metabolism of various drugs, including combined oral contraceptives, cyclosporin, and indinavir. In this report, we
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