H0500
1,2,3,4-Tetrahydroharmane-3-carboxylic acid
동의어(들):
1-Methyl-1,2,3,4-Tetrahydropyrido[3,4-b]indole-3-carboxylic acid, 1-Methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid, NSC 26225
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100 MG
₩160,878
About This Item
실험식(Hill 표기법):
C13H14N2O2
CAS Number:
Molecular Weight:
230.26
MDL number:
UNSPSC 코드:
12352100
PubChem Substance ID:
NACRES:
NA.22
추천 제품
![1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole 98%](/deepweb/assets/sigmaaldrich/product/structures/181/460/3d58bc34-1b5c-4295-bbac-3b52085670e8/640/3d58bc34-1b5c-4295-bbac-3b52085670e8.png)
저장 온도
−20°C
SMILES string
CC1NC(Cc2c1[nH]c3ccccc23)C(O)=O
InChI
1S/C13H14N2O2/c1-7-12-9(6-11(14-7)13(16)17)8-4-2-3-5-10(8)15-12/h2-5,7,11,14-15H,6H2,1H3,(H,16,17)
InChI key
ZUPHXNBLQCSEIA-UHFFFAOYSA-N
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애플리케이션
Reactant involved in synthesis of molecules for biological studies including:
- Cytotoxicity and insecticidal activities of harmine derivatives
- Isoquinolines, β-carbolines, and 3-deazapurines via oxidative decarboxylation
- Cytotoxic evaluation of 1,3-di- and 1,3,9-trisubstituted β-carbolines
생화학적/생리학적 작용
Implicated in eosinophilia-myalgia syndrome associated with L-tryptophan ingestion.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
J Adachi et al.
Biochemical pharmacology, 45(4), 935-941 (1993-02-24)
1-Methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA) is one of the metabolites of peak E substance, which, based on epidemiological studies, has been thought to be a possible causative agent of the tryptophan-induced eosinophilia-myalgia syndrome. Acute ethanol and L-tryptophan administration in rats pretreated with
K Fujie et al.
Mutation research, 240(4), 281-288 (1990-04-01)
The acute cytogenetic effects of tyramine and MTCAs, precursors of the mutagen present in soy sauce, were studied with the in vivo chromosome aberration test in rat bone marrow cells. The chemicals were administered intraperitoneally. Statistically significant positive results were
J Adachi et al.
Archives of toxicology, 65(6), 505-509 (1991-01-01)
1-Methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA) is now thought to be a possible causative substance of eosinophilia-myalgia syndrome associated with ingestion of L-tryptophan. In the present study a factor affecting endogenous formation of MTCA in 32 healthy men is studied. Urinary excretions of
S Manabe et al.
Experimental eye research, 63(2), 179-186 (1996-08-01)
A fluorescent beta-carboline, 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3- carboxylic acid (MTCA) was identified in human normal lenses and cataractous lenses. The mean total amounts of MTCA in normal lenses (n = 7), diabetic cataractous lenses (n = 15), and senile cataractous lenses (n =
H Tsuchiya et al.
Journal of pharmaceutical sciences, 83(3), 415-418 (1994-03-01)
A high-performance liquid chromatographic method was developed to quantify 1,2,3,4-tetrahydro-beta-carboline (TBC) and 1-methyl-1,2,3,4-tetrahydro-beta-carboline (MTBC) in human urine. Urine samples with added internal standard were subjected to a reaction with fluorescamine and solvent extractions to remove the precursor tryptamine, which readily
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