추천 제품
![2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/376/664/07577eb6-6e8c-4237-b8c5-03da4c8e7d88/640/07577eb6-6e8c-4237-b8c5-03da4c8e7d88.png)
분석
98%
양식
liquid
mp
206-208 °C (lit.)
SMILES string
C1Cc2c(CN1)[nH]c3ccccc23
InChI
1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2
InChI key
CFTOTSJVQRFXOF-UHFFFAOYSA-N
유전자 정보
rat ... Htr2a(29595) , Htr2c(25187)
일반 설명
Ozonolysis of the enamine bond of 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole derivatives was studied.[1]
애플리케이션
1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole was employed in alkaloid synthesis[2] and in studies on neurodegenerative diseases.[3][4]
- Reactant for synthesis of the indolyl-β-carboline alkaloid eudistomin U via IBX mediated room temperature oxidative aromatization
- Reactant for preparation of neuroprotective HDAC6 inhibitors
- Reactant for preparation of aminofuranopyrimidines as EGFR and Aurora A kinase inhibitors
- Reactant for preparation of inhibitors of CDK4
- Reactant for preparation of tetrahydrocarboline derivatives of as human 5-HT5A receptor ligands
- Reactant for preparation of 5-(diaminomethyl)-2,4-aminopyrimidines as dihydrofolate reductase inhibitors and antibacterial agents
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Minoru Tanaka et al.
Bioorganic & medicinal chemistry, 21(5), 1159-1165 (2013-01-23)
Indoleamine 2,3-dioxygenase (IDO) plays a significant role in several disorders such as Alzheimer's disease, age-related cataracts and tumors. A series of novel tryptoline derivatives were synthesized and evaluated for their inhibitory activity against IDO. Substituted tryptoline derivatives (11a, 11c, 11e
Fang-Yuan Chang et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(7), 2478-2483 (2013-01-11)
Natural product discovery by random screening of broth extracts derived from cultured bacteria often suffers from high rates of redundant isolation, making it ever more challenging to identify novel biologically interesting natural products. Here we show that homology-based screening of
Chem. Abstr., 121, 54854s-54854s (1994)
I M McDonald et al.
Journal of medicinal chemistry, 43(19), 3518-3529 (2000-09-23)
A novel series of nonpeptide CCK(2) receptor antagonists has been prepared, in which 2,7-dioxo-2,3,4,5,6,7-hexahydro-1H-benzo[h][1, 4]diazonine (5) was used as a chemical template. This uncommon ring system was obtained in a highly substituted form and in high yield by ozonolysis of
J. Chin. Chem. Soc., 41, 231-231 (1994)
활성 필터
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