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일반 설명
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Gc-globulin from human plasma is encoded by the gene GC, which is mapped to human chromosome 4q13.3.[1]
애플리케이션
Gc-globulin from human plasma has been used:
- as a fluorescent probe for G-actin staining[4]
- as a fluorescent probe to monitor steady-state rate of actin filament disassembly[5]
- as a calibrator for liquid chromatography with mass spectrometry (LC-MS/MS)[6]
Gc-globulin is a multifunctional, albumin-like plasma protein that often requires cell surface binding to mediate some of its diverse functions.[7] It has been used to anlayze its glycosylation patterns.
생화학적/생리학적 작용
Gc-Globulin, a member of the albumin superfamily, is the major plasma carrier of vitamin D and its metabolites. It is also, along with gelsolin, a part of the extracellular actin scavenger system. Gc-globulin also binds monomeric actin (G-actin) with high affinity to scavenge actin released by necrotic cells, preventing its polymerization into filaments. Gc-globulin enhances the chemoattractant activity of C5a for inflammatory cells.
Single nucleotide polymorphism in the gene GC is associated with deficiency of 25-hydroxyvitamin D [25(OH)D].[1]
제조 메모
Native Gc-globulin from human plasma
면책조항
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
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J Greilberger et al.
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V F Rusiaev
Meditsinskaia tekhnika, (3)(3), 36-40 (1987-05-01)
A conductometric method for studying flowing blood coagulation is proposed. Phases of conductograms characterizing the kinetics and intensity of blood cells aggregation, release of biologically active compounds, fibrin formation, its mechanical properties, retraction process and fibrinolysis of clot are analysed
David Palmer et al.
Internal medicine journal, 52(1), 89-94 (2020-10-12)
Free concentrations of highly protein bound hormones, such as cortisol and thyroxine, are unchanged in critical illness despite substantial decreases in total concentration. Total 25-hydroxyvitamin D (25(OH)D) concentration is decreased in critical illness, but the free concentration of 25(OH)D has
The GC, CYP2R1 and DHCR7 genes are associated with vitamin D levels in northeastern Han Chinese children
Zhang Y, et al.
Swiss Medical Weekly, 142(2930) (2012)
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