G2879

Glycine hydrochloride

≥99% (HPLC)

• 동의어(들): Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll
• Linear Formula: H₂NCH₂CO₂H · HCl
• CAS Number: 6000-43-7
• Molecular Weight: 111.53
• EC Number: 227-841-8
• MDL number: MFCD00012872
• UNSPSC 코드: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24895108
• NACRES: NA.32

속성

• 분석: ≥99% (HPLC)
• 형태: powder
• 분자량: 111.53
• 저장 조건: (Tightly closed Dry)
• 농도: ≤100%
• 기술: immunohistochemistry: suitable
• mp: 176-180 °C (lit.)
• solubility: water: 0.5 g/mL, clear, colorless
• 저장 온도: room temp
• SMILES string: Cl.NCC(O)=O
• InChI: 1S/C2H5NO2.ClH/c3-1-2(4)5;/h1,3H2,(H,4,5);1H
• InChI key: IVLXQGJVBGMLRR-UHFFFAOYSA-N

설명

일반 설명

Research area: Neuroscience

애플리케이션

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.

Glycine hydrochloride has been used:

• in the preparation of glycine-HCl buffer
• to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
• to regenerate the sensor to elute the bound C-reactive protein (CRP)

생화학적/생리학적 작용

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.

Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

안전성 정보

• 픽토그램: GHS05
• 신호어: Danger
• 유해 및 위험 성명서: H314
• 예방조치 성명서: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Eye Dam. 1 - Skin Corr. 1
• Storage Class Code: 8A - Combustible corrosive hazardous materials
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)