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Merck
모든 사진(4)

문서

G2128

Sigma-Aldrich

L-Glutamic acid hydrochloride

동의어(들):

(S)-2-Aminoglutaric acid, (S)-2-Aminopentanedioic acid ammonium salt, Glu HCl

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About This Item

실험식(Hill 표기법):
C5H9NO4 · HCl
CAS Number:
Molecular Weight:
183.59
Beilstein:
3565569
EC Number:
MDL number:
UNSPSC 코드:
12352106
PubChem Substance ID:
NACRES:
NA.32

SMILES string

Cl.N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1

InChI key

RPAJSBKBKSSMLJ-DFWYDOINSA-N

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관련 카테고리

일반 설명

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors.

애플리케이션

L-Glutamic acid hydrochloride has been used as a nutrient additive to study the effect of increased dissolved inorganic nitrogen (DIN) on the uptake of dissolved organic nitrogen (DON) and dissolved organic carbon (DOC), in a nitrogen-limited headwater forest stream.

생화학적/생리학적 작용

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Huntington′s disease and Parkinson′s disease. Glutamate is also responsible for the activation of long-term potentiation (LTP) and long-term depression (LTD). Induction of glutamate receptors plays a key role in the pathophysiology of migraine.
Agonist at kainate, NMDA, and quisqualate receptors; an excitatory amino acid neurotransmitter.

픽토그램

Corrosion

신호어

Danger

유해 및 위험 성명서

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


시험 성적서(COA)

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문서 라이브러리 방문

Coupled cycling of dissolved organic nitrogen and carbon in a forest stream.
Brookshire E N J et al
Ecology, 86(9), 2487-2496 (2005)
B K Day et al.
Journal of neurochemistry, 96(6), 1626-1635 (2006-01-31)
L-glutamate (Glu) is the predominant excitatory neurotransmitter in the mammalian central nervous system. It plays major roles in normal neurophysiology and many brain disorders by binding to membrane-bound Glu receptors. To overcome the spatial and temporal limitations encountered in previous
Martina Curto et al.
The journal of headache and pain, 17, 47-47 (2016-05-01)
Activation of glutamate (Glu) receptors plays a key role in the pathophysiology of migraine. Both NMDA and metabotropic Glu receptors are activated or inhibited by metabolites of the kynurenine pathway, such as kynureninic acid (KYNA), quinolinic acid (QUINA), and xanthurenic
Wei Lu et al.
Neuron, 78(3), 433-439 (2013-05-15)
The cell-autonomous role of synaptic transmission in the regulation of neuronal structural and electrical properties is unclear. We have now employed a genetic approach to eliminate glutamatergic synaptic transmission onto individual CA1 pyramidal neurons in a mosaic fashion in vivo. Surprisingly
A new beginning for a broken mind: balancing neuregulin 1 reverses synaptic dysfunction.
Oscar Marín et al.
Neuron, 78(4), 577-579 (2013-05-31)

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