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Merck
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주요 문서

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G1171

Sigma-Aldrich

Gö 6976

≥98% (HPLC), powder

동의어(들):

12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, Go 6976

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About This Item

실험식(Hill 표기법):
C24H18N4O
CAS Number:
136194-77-9
Molecular Weight:
378.43
MDL number:
MFCD00236434
UNSPSC 코드:
12352200
PubChem Substance ID:
329799832

분석

≥98% (HPLC)

형태

powder

색상

white

solubility

DMSO: >5 mg/mL

저장 온도

−20°C

SMILES string

Cn1c2ccccc2c3c4C(=O)NCc4c5c6ccccc6n(CCC#N)c5c13

InChI

1S/C24H18N4O/c1-27-17-9-4-2-7-14(17)20-21-16(13-26-24(21)29)19-15-8-3-5-10-18(15)28(12-6-11-25)23(19)22(20)27/h2-5,7-10H,6,12-13H2,1H3,(H,26,29)

InChI key

VWVYILCFSYNJHF-UHFFFAOYSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Gö 6976 has been used:
  • as an inhibitor of protein kinase C (PKC) in mammalian cell lines
  • as a PKCμ inhibitor in oocytes
  • as a PKC-α to test its effect on phosphorylation of protein kinase-B (Akt) and extracellular-signal-regulated kinase (ERK) levels

생화학적/생리학적 작용

Go¨6976 also acts as an effective inhibitor of protein kinase C isoform (PKCμ) and abolishes phorbol ester mediated potentiation in oocytes. It inhibits PKC α and β selectively. Go-6976 may also inhibit S6-kinase 1.
Gö 6976 is an inhibitor of protein kinase C (PKC) specific for α (IC50=2.3 nM) and β1 (IC50=6.2 nM) isozymes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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문서 라이브러리 방문

Katherine A Robinson et al.
PloS one, 9(10), e108963-e108963 (2014-10-21)
Chronic hyperglycemia induces insulin resistance by mechanisms that are incompletely understood. One model of hyperglycemia-induced insulin resistance involves chronic preincubation of adipocytes in the presence of high glucose and low insulin concentrations. We have previously shown that the mTOR complex
Hairuo Wen et al.
Journal of neurochemistry, 108(2), 331-340 (2008-12-03)
The potentiation of P2X(1) receptor currents by phorbol ester (PMA) treatment and stimulation of mGluR1alpha receptors was sensitive to inhibition of novel forms of protein kinase C. Potentiation was also reduced by co-expression of an amino terminal P2X(1) receptor minigene.
Shaon Naskar et al.
PloS one, 9(8), e104711-e104711 (2014-08-15)
A cardiac hypertrophy is defined as an increase in heart mass which may either be beneficial (physiological hypertrophy) or detrimental (pathological hypertrophy). This study was undertaken to establish the role of different protein kinase-C (PKC) isoforms in the regulation of
Wei Cao et al.
Antioxidants & redox signaling, 18(1), 19-35 (2012-06-06)
Activation of intrarenal renin-angiotensin system (RAS) has a detrimental effect on the progression of chronic kidney diseases (CKDs), although the regulation of intrarenal RAS remains unclear. The aim of the present study was to evaluate the role of advanced oxidation
Jianwei Wang et al.
PloS one, 7(9), e45043-e45043 (2012-10-03)
Protein kinase C (PKC) is involved in gonadotrophin-induced oocyte maturation. In the present study, we investigated the role of specific PKC isoforms in the process of follicle-stimulating hormone (FSH)-induced oocyte meiotic resumption. Small antral follicles (200-300 µm in diameter) were
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