G117
Glipizide
solid
동의어(들):
1-Cyclohexyl-3-{4-[2-(5-methylpyrazine-2-carboxamido)ethyl]phenylsulfonyl}urea
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모든 사진(3)
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500 MG
₩207,872
1 G
₩380,727
About This Item
실험식(Hill 표기법):
C21H27N5O4S
CAS Number:
Molecular Weight:
445.54
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
양식
solid
Quality Level
색상
white
solubility
methanol: 1.9 mg/mL
DMSO: 48 mg/mL
SMILES string
Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
InChI
1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28)
InChI key
ZJJXGWJIGJFDTL-UHFFFAOYSA-N
유전자 정보
human ... ABCC8(6833) , KCNJ1(3758) , KCNJ11(3767)
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일반 설명
Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) codes for a renal outer medullary potassium channel (ROMK1, Kir1.1).[1] Glipizide is an antidiabetic drug, that is used to treat type II diabetes.(5)
애플리케이션
Glipizide has been used in:
- chick embryo yolk sac membrane (YSM) and chorioallantoic membrane (CAM) assay[2]
- MCF-7 breast cancer assay on chorioallantoic membrane (CAM)[2]
- metastasis assays[2][3]
- rat aortic ring assay[3]
- in vivo matrigel plug assay
- 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay[3]
- flow cytometry[3]
- western blotting[3]
생화학적/생리학적 작용
Potassium inwardly-rectifying channel, subfamily J, member 1 (KCNJ1) plays a vital role in potassium balance.[4] It is an ATP-dependent K+ channel blocker. The encoded protein is liable for the elimination of potassium in exchange for the absorption of sodium by the epithelial sodium channel (ENaC).[1] Mutation in KCNJ1 is linked with several diseases, such as, antenatal Bartter syndrome and diabetes.[4] Glipizide helps to repress the development of tumors and metastasis by preventing angiogenesis.[2]
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Glipizide suppresses prostate cancer progression in the TRAMP model by inhibiting angiogenesis
Qi C, et al.
Scientific reports, 6(20), 27819-27819 (2016)
Association of KCNJ1 variation with change in fasting glucose and new onset diabetes during HCTZ treatment
Karnes JH, et al.
The Pharmacogenomics Journal, 13(5), 430-430 (2013)
KCNJ1 inhibits tumor proliferation and metastasis and is a prognostic factor in clear cell renal cell carcinoma
Guo Z, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 36(2), 1251-1259 (2015)
K M Pantalone et al.
Diabetes, obesity & metabolism, 14(9), 803-809 (2012-04-11)
It remains uncertain if differences in mortality risk exist among the sulfonylureas, especially in patients with documented coronary artery disease (CAD). The purpose of this study was to assess the overall mortality risk of the individual sulfonylureas versus metformin in
Korbinian Löbmann et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 81(1), 159-169 (2012-02-23)
The objective of this study was to prepare a co-amorphous drug/drug combination between two BCS class II drugs, simvastatin (SVS) and glipizide (GPZ). This pharmacologically relevant combination of two drugs could produce a promising candidate for formulations intended for combination
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