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Merck
모든 사진(3)

Key Documents

F6300

Sigma-Aldrich

Flumazenil

>99% (HPLC), solid, benzodiazepine receptor antagonist

동의어(들):

Ro 15-1788, Ro15-1788

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About This Item

실험식(Hill 표기법):
C15H14FN3O3
CAS Number:
Molecular Weight:
303.29
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77

product name

Flumazenil, >99% (HPLC), solid

Quality Level

분석

>99% (HPLC)

형태

solid

색상

white

주관자

Roche

저장 온도

2-8°C

SMILES string

CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23

InChI

1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3

InChI key

OFBIFZUFASYYRE-UHFFFAOYSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.

생화학적/생리학적 작용

Highly specific benzodiazepine receptor antagonist.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


시험 성적서(COA)

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문서 라이브러리 방문

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Nahid Amini et al.
Analytical and bioanalytical chemistry, 405(4), 1303-1310 (2012-11-28)
A general method is presented for the identification of radiometabolites in plasma of human and monkey subjects after administration of positron emission tomography (PET) radioligands. The radiometabolites are first produced in vitro, using liver microsomes, subsequently separated using fast radio-liquid
Stina Syvänen et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(12), 1974-1983 (2012-11-13)
The aim of the present study was to investigate if flumazenil blood-brain barrier transport and binding to the benzodiazepine site on the γ-aminobutyric acid A (GABA(A)) receptor complex is altered in an experimental model of epilepsy and subsequently to study
David B Rye et al.
Science translational medicine, 4(161), 161ra151-161ra151 (2012-11-24)
The biology underlying excessive daytime sleepiness (hypersomnolence) is incompletely understood. After excluding known causes of sleepiness in 32 hypersomnolent patients, we showed that, in the presence of 10 μM γ-aminobutyric acid (GABA), cerebrospinal fluid (CSF) from these subjects stimulated GABA(A)
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Annals of the New York Academy of Sciences, 1268, 26-34 (2012-09-22)
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In psychopharmacology, researchers have been interested in the hypnotic effects of terrestrial plant polyphenols and their synthetic derivatives. Phlorotannins, a marine plant polyphenol, could have potential as a source of novel hypnotic drugs. The effects of phlorotannins and major phlorotannin

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