E9658

Enalaprilat dihydrate

≥98% (HPLC)

• 동의어(들): (2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenyl-propyl]amino]propanoyl]pyrrolidine-2-carboxylic acid, Vasotec
• 실험식(Hill 표기법): C₁₈H₂₄N₂O₅ ·2H₂O
• CAS Number: 84680-54-6
• Molecular Weight: 384.42
• EC Number: 278-459-3
• MDL number: MFCD00941393
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329799089
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• solubility: H₂O: 14 mg/mL at 60 °C (warming for 5 minutes); DMSO: 64 mg/mL
• 주관자: Merck & Co., Inc., Kenilworth, NJ, U.S.
• 저장 온도: room temp
• SMILES string: O.O.C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N2CCC[C@H]2C(O)=O
• InChI: 1S/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2/t12-,14-,15-;;/m0../s1
• InChI key: MZYVOFLIPYDBGD-MLZQUWKJSA-N
• 유전자 정보: human ... ACE(1636)

설명

생화학적/생리학적 작용

Enalapril, the ethyl ester of enalaprilat exhibits slight pharmacological activity until it is hydrolyzed in the liver to enalaprilat.[1] Enalaprilat, a IV form of an angiotensin-converting-enzyme inhibitor (ACE) prevents the transformation of angiotensin I to angiotensin II, a potent vasoconstrictor.[2]

Enalaprilat is an inhibitor of angiotensin converting enzyme (ACE), antihypertensive, and a Bradykinin B1 receptor activator. Enalaprilat has nM potency versus ACE and also activates B1 receptors to release NO.

특징 및 장점

This compound is featured on the Angiotensin Receptors and Bradykinin Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)