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D8893

Sigma-Aldrich

Dexamethasone

powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC)

동의어(들):

(11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16α-methylprednisolone, Prednisolone F

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크기 선택

1 MG
₩127,890

₩127,890

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청
모든 사진(1)

크기 선택

보기 변경
1 MG
₩127,890

About This Item

실험식(Hill 표기법):
C22H29FO5
CAS Number:
50-02-2
Molecular Weight:
392.46
Beilstein:
2066651
EC Number:
200-003-9
MDL number:
MFCD00064136
UNSPSC 코드:
12352209
PubChem Substance ID:
24894235
NACRES:
NA.77

₩127,890

구입 가능 여부는 고객센터에 문의하십시오.
벌크 견적 요청

생물학적 소스

synthetic (organic)

Quality Level

200

무균

γ-irradiated

제품 라인

BioXtra

분석

≥80% (HPLC)

양식

powder

효능

4-500 ng/mL

기술

cell culture | mammalian: suitable

mp

262-264 °C (lit.)

solubility

ethanol: 1 mL/vial, clear

배송 상태

ambient

저장 온도

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

유전자 정보

human ... ABCB1(5243) , CYP3A4(1576) , IL4(3565) , IL5(3567) , NR3C1(2908)
mouse ... Abcb1a(18671) , Abcb1b(18669) , Ifng(15978) , Nos2(18126) , Ptgs2(19225) , Tnf(21926)
rat ... Ar(24208) , Nr3c1(24413) , Tnf(24835)

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관련 카테고리

애플리케이션

Dexamethasone has been used as a component of osteogenic differentiation medium.[1][2][3] It has also been used to study apoptosis, cell signaling pathways and gene expression.

생화학적/생리학적 작용

Dexamethasone has immunosuppressant and antiemetic properties. It is used to treat postoperative nausea and vomiting (PONV) and chemotherapy-induced nausea and vomiting (CINV).[4] Dexamethasone plays an important role in cardiac transplant, sepsis, cancer and other pathologic disorders. It elevates the level of heat shock proteins.[5] It is an anti-inflammatory glucocorticoid with a range of effects on cell survival, cell signaling and gene expression.
Glucocorticoid anti-inflammatory agent
Glucocorticoid anti-inflammatory agent. Regulates T cell survival, growth, and differentiation. Inhibits the induction of nitric oxide synthase.

물리적 형태

powder 2-8 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw

재구성

To prepare 20 μg/ml stock solution: add 1 ml absolute ethanol; gently swirl to dissolve; add 49 ml sterile medium while mixing.

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H360FD

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
SLCK6126
SLCK8842
SLCD7888
SLBZ2775
SLBR5750V

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Bimolecular based heparin and self-assembling hydrogel for tissue engineering applications
Fernandez-Muinos T, et al.
Acta Biomaterialia, 16(5), 35-48 (2015)
Pharmacology and Physiology for Anesthesia: Foundations and Clinical Application (2013)
Substrate elasticity regulates adipose-derived stromal cell differentiation towards osteogenesis and adipogenesis through $\beta$-catenin transduction
Xie J, et al.
Acta Biomaterialia, 79(5), 83-95 (2018)
The Unfolded Protein Response and Cellular Stress, Part 2 (2011)
C A Smith et al.
Journal of tissue engineering and regenerative medicine, 9(5), 595-604 (2014-06-20)
Fresh-frozen biological allograft remains the most effective substitute for the 'gold standard' autograft, sharing many of its osteogenic properties but, conversely, lacking viable osteogenic cells. Tissue engineering offers the opportunity to improve the osseointegration of this material through the addition
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질문

1–6 / 6 질문  

  1. What is the Department of Transportation shipping information for this product?

    1 답변

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  2. What is the solubility of Product D8893, Dexamethasone, in ethanol?

    1 답변

    1. The product is soluble in 95% ethanol (1mg/mL), yielding a clear, colorless solution. A 20 μg/mL stock solution can be formed by adding 49 mL of media to 1 mL of a 1 mg/mL ethanol stock.

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  3. What is the best way to dissolve Product D8893, Dexamethasone?

    1 답변

    1. The solubility of dexamethasone is <0.01 mg/mL in water and 24 mg/mL in H5784 (a 45% w/v solution of 2-hydroxypropyl-β-cyclodextrin).

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  4. How do the dexamethasone products D8893 and the D4902 compare?

    1 답변

    1. They are the same except for the sterility. D8893 has been g-irradiated, so it is sterile. The D4902 is not necessarily sterile. Both are cell culture tested by Sigma.

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  5. What is the solubility of Product D8893, Dexamethasone, in DMSO?

    1 답변

    1. The solubility of dexamethasone in DMSO is 606 mg/mL at 25°C.

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  6. What solution stability information do you have available for Product D8893, Dexamethasone?

    1 답변

    1. We would recommend that you store stock solutions in working aliquots frozen at -20°C. It is best to avoid repeated freeze/thaw cycles.

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