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Merck
모든 사진(1)

주요 문서

D7011

Sigma-Aldrich

Deoxyribonucleic acid sodium salt from human placenta

Type XIII

동의어(들):

hpDNA, DNA

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모든 사진(1)

About This Item

CAS Number:
9007-49-2
MDL number:
MFCD00130922
UNSPSC 코드:
41106305
NACRES:
NA.51

유형

Type XIII

양식

powder

저장 온도

2-8°C

InChI

1S/C15H31N3O13P2/c16-13-1-7(20)11(28-13)5-25-32(21,22)31-9-3-15(18)29-12(9)6-26-33(23,24)30-8-2-14(17)27-10(8)4-19/h7-15,19-20H,1-6,16-18H2,(H,21,22)(H,23,24)

InChI key

AWBASQCACWFTGD-UHFFFAOYSA-N

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일반 설명

Deoxyribonucleic acid (DNA) from placenta and its methylation pattern is indicative of anomalies in the fetal growth.[1] Tobacco smoking during pregnancy favors methylation and epigenetic modulation of placental DNA.[2]

애플리케이션

Deoxyribonucleic acid sodium salt from human placenta has been used:
  • as a standard for optimization of digestion followed by high-performance liquid chromatography (HPLC) and mass spectroscopy[3]
  • as a standard for ultra violet (UV) spectrophotometer measurements[4]
  • in polymerase chain reaction (PCR) assay and for standard curve generation for human papillomavirus type 6 quantification[5]

Human placenta DNA (hpDNA) is a natural DNA used in studies of DNA binding anticancer agents and DNA binding agents that modulate DNA structure and function. Human placenta DNA is also used in physicochemical studies of DNA behavior in solution.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
SLBF0459V
SLBF5124V
109K3775
079K3791
127K37791

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Results from the NIST 2004 DNA quantitation study
Kline MC, et al.
Journal of Forensic Sciences, 50(3), 1-8 (2005)
DNA methylation in the human placenta and fetal growth
Koukoura O, et al.
Molecular Medicine Reports, 5(4), 883-889 (2012)
Johan S Nilsson et al.
Scientific reports, 9(1), 15432-15432 (2019-10-30)
Nasopharyngeal cancer (NPC) is associated with the Epstein-Barr virus (EBV). The clinical presentation and prognosis of NPC is well described, but not in relation to intralesional EBV-DNA load. In a retrospective design, 48 patients with NPC were examined. Patient history
Genome-wide DNA methylation study in human placenta identifies novel loci associated with maternal smoking during pregnancy
Morales E, et al.
International Journal of Epidemiology, 45(5), 1644-1655 (2016)
Viral load and m RNA expression of HPV type 6 among cases with recurrent respiratory papillomatosis
Forslund O, et al.
Laryngoscope, 126(1), 122-127 (2016)
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질문

  1. This item (D7011) has been discontinued. Can you please let me know what the comparable product is?

    1 답변

    1. Product D3035, is a solution of Deoxyribonucleic acid prepared from human placenta at a concentration of 0.05 mg/mL (the 0.1 mg pack size would be 2 mL) and would be the closest equivalent alternative to the discontinued D7011. Please see the link below to review this product:
      https://www.sigmaaldrich.com/product/sigma/d3035

      If a powdered form is preferred we do offer comparable alternatives such as 11691112001 from Roche, Human Genomic DNA from human blood (buffy coat). It is not from human placenta but prepared from 100 to 200 individual blood donors of both sexes (pool of the buffy coat). If the DNA from another species is compatible in your application, products D1626 (from salmon) or D6898 (from herring) are options to consider.

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