D1822

Doxycycline monohydrate

• 동의어(들): 6-Deoxy-5-oxytetracycline monohydrate, Doxycycline
• 실험식(Hill 표기법): C₂₂H₂₄N₂O₈ · H₂O
• CAS Number: 17086-28-1
• Molecular Weight: 462.45
• MDL number: MFCD02682958
• UNSPSC 코드: 51284030
• PubChem Substance ID: 329798712
• NACRES: NA.85

속성

• 양식: powder or crystals
• Quality Level: 200
• 항생제 활성 스펙트럼: Gram-negative bacteria; Gram-positive bacteria; mycoplasma; parasites
• 동작 모드: protein synthesis | interferes
• 저장 온도: −20°C
• SMILES string: O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
• InChI: 1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
• InChI key: XQTWDDCIUJNLTR-CVHRZJFOSA-N
• 유전자 정보: human ... MMP1(4312) , MMP13(4322) , MMP7(4316) , MMP8(4317)

설명

애플리케이션

• In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
• It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
• It has also been used as an antimicrobial agent.

생화학적/생리학적 작용

Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 + P330 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable