콘텐츠로 건너뛰기
Merck
모든 사진(1)

주요 문서

모든 문서 보기

C9705

Sigma-Aldrich

Concanamycin A

≥70% (HPLC), crystals, vacuolar-type v-ATPase inhibitor

동의어(들):

Folimycin

로그인조직 및 계약 가격 보기

크기 선택

25 μG
₩380,727
0.1 MG
₩1,123,605

₩380,727

출고 가능일2025년 4월 09일세부사항

벌크 견적 요청
모든 사진(1)

크기 선택

보기 변경
25 μG
₩380,727
0.1 MG
₩1,123,605

About This Item

실험식(Hill 표기법):
C46H75NO14
CAS Number:
80890-47-7
Molecular Weight:
866.09
Beilstein:
3560277
MDL number:
MFCD00210037
UNSPSC 코드:
12352200
PubChem Substance ID:
24893186
NACRES:
NA.77

₩380,727

출고 가능일2025년 4월 09일세부사항

벌크 견적 요청

제품명

Concanamycin A, ≥70% (HPLC)

Quality Level

200

분석

≥70% (HPLC)

양식

solid film

항생제 활성 스펙트럼

viruses

동작 모드

enzyme | inhibits

저장 온도

−20°C

SMILES string

CCC1C(O)C(C)C\C(C)=C\C=C\C(OC)C(OC(=O)\C(OC)=C\C(C)=C\C(C)C1O)C(C)C(O)C(C)[C@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)C(O2)\C=C\C

InChI

1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26?,27?,28-,29?,30?,31-,32?,33-,34?,35?,37-,38+,39?,40?,41?,42?,43-,46+/m1/s1

InChI key

DJZCTUVALDDONK-LWLXYWDNSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

관련 카테고리

일반 설명

Chemical structure: macrolide
Concanamycin A belongs to the plecomacrolide family[1] and comprises an 18-membered tetraenic macrolide ring.[2]

애플리케이션

Concanamycin A has been used:
  • as a lysosomal inhibitor in young and old fibroblasts[3]
  • as a vacuolar-type H+-ATPase inhibitor in presynaptic vesicles[4]
  • as a lysosomal acidification blocker in HepG2 hepatocytes cells[5]

생화학적/생리학적 작용

Concanamycin A (ConA) inhibits acidification of organelles[1] and perforin-mediated cytotoxicity.[6] It is a vacuolar-type v-ATPase inhibitor.[7] ConA possesses antiprotozoal and antineoplastic properties.[2] It mediates inhibition of the negative factor (Nef) protein of the human immunodeficiency virus.[1]

픽토그램

Skull and crossbones
GHS06

신호어

Danger

유해 및 위험 성명서

H300 + H310 + H330,H319

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
0000430747
0000430745
0000430745
0000430747
0000383099

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Hideaki Toda et al.
Developmental and comparative immunology, 35(1), 88-93 (2010-09-04)
T cell-mediated cytotoxicity occurs via pathways based on perforin or Fas mechanisms. Perforin is a protein present in the cytoplasmic granules of CD8(+) cytotoxic T lymphocytes and is secreted to form pores on target cell membranes. In fish, although the
Stephen F Haydock et al.
Microbiology (Reading, England), 151(Pt 10), 3161-3169 (2005-10-07)
The macrolide antibiotic concanamycin A has been identified as an exceptionally potent inhibitor of the vacuolar (V-type) ATPase. Such compounds have been mooted as the basis of a potential drug treatment for osteoporosis, since the V-ATPase is involved in the
Christiane Ott et al.
Redox biology, 10, 266-273 (2016-11-09)
The overall decrease in proteolytic activity in aging can promote and accelerate protein accumulation and metabolic disturbances. To specifically analyze changes in macroautophagy (MA) we quantified different autophagy-related proteins (ATGs) in young, adult and old murine tissue as well as
Mark M Painter et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(38), 23835-23846 (2020-09-10)
Nef is an HIV-encoded accessory protein that enhances pathogenicity by down-regulating major histocompatibility class I (MHC-I) expression to evade killing by cytotoxic T lymphocytes (CTLs). A potent Nef inhibitor that restores MHC-I is needed to promote immune-mediated clearance of HIV-infected
Jörn Dengjel et al.
Molecular & cellular proteomics : MCP, 11(3), M111-M111 (2012-02-09)
Autophagy is one of the major intracellular catabolic pathways, but little is known about the composition of autophagosomes. To study the associated proteins, we isolated autophagosomes from human breast cancer cells using two different biochemical methods and three stimulus types:
모든 관련된 서류 보기

질문

후기

평점 값 없음

활성 필터

자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

고객지원팀으로 연락바랍니다.