C7291

Clomipramine hydrochloride

≥98% (HPLC), powder

• 동의어(들): 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride
• 실험식(Hill 표기법): C₁₉H₂₃ClN₂ · HCl
• CAS Number: 17321-77-6
• Molecular Weight: 351.31
• EC Number: 241-344-3
• MDL number: MFCD00069234
• UNSPSC 코드: 12352116
• PubChem Substance ID: 24278087
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to off-white
• solubility: H₂O: 25 mg/mL; 0.1 M HCl: soluble
• 주관자: Novartis
• SMILES string: Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13
• InChI: 1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
• InChI key: WIMWMKZEIBHDTH-UHFFFAOYSA-N
• 유전자 정보: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

설명

일반 설명

Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.

애플리케이션

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.

Clomipramine hydrochloride has been used:

• to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
• to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
• as a serotonin reuptake inhibitor
• as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor

생화학적/생리학적 작용

Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.

Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

특징 및 장점

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS08,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H302,H336,H370,H410
• 예방조치 성명서: P260 - P264 - P271 - P273 - P301 + P312 - P308 + P311
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3
• 표적 기관: Central nervous system, Central nervous system,Cardiovascular
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves