C4780
Coenzyme A sodium salt hydrate
BioReagent, suitable for cell culture
동의어(들):
CoA Na2
로그인조직 및 계약 가격 보기
모든 사진(4)
크기 선택
보기 변경
10 MG
₩170,216
25 MG
₩261,160
100 MG
₩654,066
About This Item
실험식(Hill 표기법):
C21H36N7O16P3S · xNa+ · yH2O
CAS Number:
Molecular Weight:
767.53 (anhydrous free acid basis)
EC Number:
MDL number:
UNSPSC 코드:
12352205
PubChem Substance ID:
NACRES:
NA.75
추천 제품
생물학적 소스
yeast
설명
cofactor for acyl transfer
제품 라인
BioReagent
분석
≥85% (HPLC)
양식
powder
기술
cell culture | mammalian: suitable
solubility
water: 50 mg/mL, clear, colorless to faintly yellow
저장 온도
−20°C
SMILES string
[Na+].CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS
InChI
1S/C21H36N7O16P3S.Na/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H
InChI key
SYTRWOCXZXQBPW-CLVRNSBASA-M
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애플리케이션
Coenzyme A sodium salt hydrate has been used:
- in the branch chain aminotransferase enzymatic assay and protein determination
- in the assay for halogenation of pyrrolyl-S-Bmp1 (an acyl carrier protein (ACP)-thioesterase (TE) di-domain protein) by Bmp2
- as an extracellular coenzyme A (CoA) in in vitro and in vivo experiments to study alternative routes by which cells and organisms can obtain CoA
생화학적/생리학적 작용
Coenzyme A (CoA) is a ubiquitous cofactor that plays an important role in many metabolic pathways, mainly as acyl-CoA. It is essential for the tricarboxylic acid cycle, and the synthesis and oxidation of fatty acids. CoA facilitates acyl group transfers, especially in fatty acid and lipid metabolism reactions. It is associated with neurodegeneration, autophagy, protein acetylation, and signal transduction.
품질
Enzymatically assayed using phosphotransacetylase. Approx. 95% CoA-SH
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
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시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Balaji Srinivasan et al.
Nature chemical biology, 11(10), 784-792 (2015-09-01)
The metabolic cofactor coenzyme A (CoA) gained renewed attention because of its roles in neurodegeneration, protein acetylation, autophagy and signal transduction. The long-standing dogma is that eukaryotic cells obtain CoA exclusively via the uptake of extracellular precursors, especially vitamin B5
Yongzhong Wei et al.
World journal of gastroenterology, 14(2), 193-199 (2008-01-12)
Nonalcoholic fatty liver disease (NAFLD) includes hepatic steatosis, nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. NAFLD is the most common liver disorder in the United States and worldwide. Due to the rapid rise of the metabolic syndrome, the prevalence of NAFLD
Yao Rong et al.
eLife, 10 (2021-08-20)
TMEM120A, a member of the transmembrane protein 120 (TMEM120) family, has a pivotal function in adipocyte differentiation and metabolism, and may also contribute to sensing mechanical pain by functioning as an ion channel named TACAN. Here we report that expression
Krista Yang et al.
STAR protocols, 2(3), 100687-100687 (2021-08-18)
Carnitine palmitoyltransferase-1 (CPT-1) is a rate-controlling enzyme for long-chain fatty acid oxidation. This manuscript provides protocols for measuring CPT-1-mediated respiration in permeabilized, adherent cell monolayers and mitochondria freshly isolated from tissue, along with examples to assess the potency and specificity
Le Tran Phuc Khoa et al.
Cell stem cell, 27(3), 441-458 (2020-07-02)
Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process
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