추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 27 kDa
종 반응성
mouse, human, rat
기술
immunohistochemistry (frozen sections): 1:600 using rat liver tissue
microarray: suitable
western blot: 1:600 using a rat liver membrane preparation
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... GJB1(2705)
mouse ... Gjb1(14618)
rat ... Gjb1(29584)
일반 설명
Connexins (Cx) are a multi-gene family of highly related proteins with molecular weights ranging from 26 to 70 kD. The structure of connexin molecules includes a cytoplasmic N-terminal region, four transmembrane domains, two extracellular loops, and a C-terminal cytoplasmic tail of varying length. Anti-Connexin 32 is developed in rabbit using synthetic peptide Lys- Arg- Ser-Pro- Gly- Thr- Gly- Ala-Gly- Leu- Ala- Glu- Lys-Ser- Asp- Arg conjugated to KLH with glutaraldehyde as immunogen.
Gap junction protein, connexin-32 (Cx32) is encoded by gap junction protein β 1 (GJB1) gene, localized on the human chromosome X. This gene is expressed in the central nervous system (CNS) in oligodendrocytes and other neuronal populations.
면역원
synthetic human/rat connexin-32 peptide (amino acids 265-279 with an N-terminally added lysine).
애플리케이션
Anti-Connexin-32 (265-279) antibody produced in rabbit has been used in western blot analysis and immunocytochemistry.
생화학적/생리학적 작용
Mutations of the gap junction protein β 1 (GJB1) gene results in the X-linked form of Charcot-Marie-tooth disease (CMTX1). Cx32 participates in the liver regeneration after partial hepatectomy.
물리적 형태
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin with 15 mM sodium azide.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis.
Michael K G Stewart et al.
PloS one, 11(4), e0154162-e0154162 (2016-04-23)
Pannexin1 (Panx1) subunits oligomerize to form large-pore channels between the intracellular and extracellular milieu that have been shown to regulate proliferation, differentiation and cell death mechanisms. These key cellular responses are ultimately necessary for normal tissue development and function but
An 8-generation family with X-linked Charcot-Marie-Tooth: Confirmation Of the pathogenicity Of a 3? untranslated region mutation in GJB1 and its clinical features
Chen DH, et al.
Muscle and Nerve, 57(5), 859-862 (2018)
Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia
Dube E, et al.
Human Reproduction, 27(8), 2285-2296 (2012)
Trichostatin a enhances gap junctional intercellular communication in primary cultures of adult rat hepatocytes
Vinken M, et al.
Toxicological Sciences, 91(2), 484-492 (2006)
Cx32 hemichannel opening by cytosolic Ca2+ is inhibited by the R220X mutation that causes Charcot-Marie-Tooth disease
Carrer A, et al.
Human Molecular Genetics, 27(1), 80-94 (2017)
문서
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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