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Merck
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C2992

Sigma-Aldrich

CFTR Inhibitor-172

≥98% (HPLC), powder, CFTR inhibitor

동의어(들):

5-[(4-Carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl-4-thiazolidinone

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크기 선택

5 MG
₩375,043
25 MG
₩1,157,405

₩375,043

출고 가능일2025년 4월 10일세부사항

벌크 견적 요청
모든 사진(1)

크기 선택

보기 변경
5 MG
₩375,043
25 MG
₩1,157,405

About This Item

실험식(Hill 표기법):
C18H10F3NO3S2
CAS Number:
307510-92-5
Molecular Weight:
409.40
MDL number:
MFCD06411408
UNSPSC 코드:
12352200
PubChem Substance ID:
24724436
NACRES:
NA.77

₩375,043

출고 가능일2025년 4월 10일세부사항

벌크 견적 요청

제품명

CFTR(inh)-172, ≥98% (HPLC), powder

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

yellow

solubility

DMSO: ≥10 mg/mL
H2O: insoluble

저장 온도

2-8°C

SMILES string

OC(=O)c1ccc(cc1)\C=C2\SC(=S)N(C2=O)c3cccc(c3)C(F)(F)F

InChI

1S/C18H10F3NO3S2/c19-18(20,21)12-2-1-3-13(9-12)22-15(23)14(27-17(22)26)8-10-4-6-11(7-5-10)16(24)25/h1-9H,(H,24,25)/b14-8+

InChI key

JIMHYXZZCWVCMI-RIYZIHGNSA-N

애플리케이션

CFTR(inh)-172 has been used to specifically inhibit cystic fibrosis transmembrane conductance regulator (CFTR) activity.[1][2] It is also used as a CFTR inhibitor Inh-172 to treat forskolin and IBMX.[3]

생화학적/생리학적 작용

CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR).
CFTR(inh)-172 is an inhibitor of the cystic fibrosis transmembrane conductance regulator (CFTR). With a Ki = 300 nM,. CFTR(inh)-172 leads to rapid, reversible and voltage-independent inhibition; it is an antidiarrheal agent in animals. CTFR(inh)-172 may be a useful tool to study animal models of cystic fibrosis and intestinal fluid loss in cholera and other secretory diarrheas. CTFR(inh)-172 is structurally-unrelated to known, but non-specific CFTR inhibitors DPC, NPPB (Cat. No. N4779) and Glibenclamide.

관련 제품

제품 번호
설명
가격

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
0000325148
0000325148
0000191100
0000191101
0000191101

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Electrophysiological evaluation of cystic fibrosis conductance transmembrane regulator (CFTR) expression in human monocytes
Ettorre M, et al.
Biochimica et biophysica acta. General subjects, 1840(10), 3088-3095 (2014)
An unexpected effect of TNF-alpha on F508del-CFTR maturation and function
Bitam S, et al.
F1000Research, 4 (2015)
Defective CFTR expression and function are detectable in blood monocytes: development of a new blood test for cystic fibrosis
Sorio C, et al.
Testing, 6(7), e22212-e22212 (2011)
Jinxue Ruan et al.
Molecular therapy. Nucleic acids, 16, 73-81 (2019-03-11)
Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Nuclease-mediated precise gene editing (PGE) represents a promising therapy for CF, for which an efficient strategy that is free
Tonghui Ma et al.
The Journal of clinical investigation, 110(11), 1651-1658 (2002-12-05)
Secretory diarrhea is the leading cause of infant death in developing countries and a major cause of morbidity in adults. The cystic fibrosis transmembrane conductance regulator (CFTR) protein is required for fluid secretion in the intestine and airways and, when
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질문

  1. Bonjour,  J'aurai voulu connaitre la stabilité de l'inhibiteur après plusieurs mois après qu'elle soit stocké sous forme de solvant. Merci

    1 답변

    1. It is recommended to aliquot and store frozen at -20°C following reconstitution. Stock solutions are stable for up to 3 months at -20°C.

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