R3405

RP-107

≥98% (HPLC), solid

• 동의어(들): 7-n-Butyl-6-(4-hydroxyphenyl)[5H]-pyrrolo[2,3-b]pyrazine
• 실험식(Hill 표기법): C₁₆H₁₇N₃O
• CAS Number: 496864-15-4
• Molecular Weight: 267.33
• MDL number: MFCD04973541
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824024

속성

• 분석: ≥98% (HPLC)
• 형태: solid
• 저장 조건: desiccated
• solubility: DMSO: >10 mg/mL; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: CCCCc1c([nH]c2nccnc12)-c3ccc(O)cc3
• InChI: 1S/C16H17N3O/c1-2-3-4-13-14(11-5-7-12(20)8-6-11)19-16-15(13)17-9-10-18-16/h5-10,20H,2-4H2,1H3,(H,18,19)
• InChI key: PRIGRJPRGZCFAS-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

RP107 is an activator of cystic fibrosis transmembrane conductance regulator (CFTR) channel. RP107 stimulates wild-type CFTR and mutated CFTR with submicromolar affinity by a cAMP-independent mechanism. EC₅₀ = 89 nM at activating CFTR-dependent C-secretion, an effect inhibited by CFTR(inh)-172 and glibenclaminde. RP107 constitutes a new example of a scaffold structure for the selective activation of CFTR receptors.

특징 및 장점

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves