C209
Clobenpropit dihydrobromide
solid
동의어(들):
VUF 9153, [(4-Chlorophenyl)methyl]-3-(1H-imidazol-4-yl)propyl ester carbamimidothioic acid dihydrobromide
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C14H17ClN4S · 2HBr
CAS Number:
Molecular Weight:
470.65
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
형태
solid
색상
white
solubility
H2O: >20 mg/mL
ethanol: 3.30 mg/mL
DMSO: >30 mg/mL
저장 온도
2-8°C
SMILES string
Br[H].Br[H].Clc1ccc(CNC(=N)SCCCc2c[nH]cn2)cc1
InChI
1S/C14H17ClN4S.2BrH/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13;;/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19);2*1H
InChI key
JIJQPEZAVLJZBO-UHFFFAOYSA-N
생화학적/생리학적 작용
Selective H3 histamine receptor antagonist that crosses the blood-brain barrier.
특징 및 장점
This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
주의사항
Hygroscopic
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Fanyin Meng et al.
Hepatology (Baltimore, Md.), 54(5), 1718-1728 (2011-07-28)
Cholangiocarcinoma (CCA) is a biliary cancer arising from damaged bile ducts. Epithelial-mesenchymal transition (EMT) occurs as epithelial cells begin to resemble mesenchymal cells leading to increased invasion potential as the extracellular matrix (ECM) degrades. Histamine exerts its effects by way
W Bäumer et al.
Allergy, 63(10), 1387-1394 (2008-09-11)
Dendritic cells (DC) are the major antigen-presenting cells and play a key role in adaptive immunity as they are able to activate naive T cells. It was recently described, that the histamine H(4) receptor (H4R) is present on human monocyte-derived
Brajesh K Rai et al.
Proteins, 78(2), 457-473 (2009-09-30)
G Protein-Coupled Receptors (GPCRs) are integral membrane proteins that play important role in regulating key physiological functions, and are targets of about 50% of all recently launched drugs. High-resolution experimental structures are available only for very few GPCRs. As a
Kasper B Hansen et al.
The Journal of pharmacology and experimental therapeutics, 333(3), 650-662 (2010-03-04)
N-Methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that mediate a slow, Ca(2+)-permeable component of excitatory synaptic transmission in the central nervous system and play a pivotal role in synaptic plasticity, neuronal development, and several neurological diseases. We describe a fluorescence-based
M Kathmann et al.
Naunyn-Schmiedeberg's archives of pharmacology, 348(5), 498-503 (1993-11-01)
We determined the affinities of nordimaprit, homodimaprit, clobenpropit and imetit for H3 binding sites (labelled by 3H-N alpha-methylhistamine) in rat brain cortex homogenates and their potencies at presynaptic H3A receptors on noradrenergic nerve endings in mouse brain cortex slices. 3H-N
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