모든 사진(2)
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100 MG
₩693,651
About This Item
실험식(Hill 표기법):
C22H30O4
CAS Number:
Molecular Weight:
358.47
MDL number:
UNSPSC 코드:
12352205
PubChem Substance ID:
NACRES:
NA.79
추천 제품
분석
≥98%
양식
powder
기술
HPLC: suitable
색상
white to off-white
저장 온도
2-8°C
SMILES string
CC(=O)OCC1(O)CC23CCC4c5ccoc5CCC4(C)C2CCC1C3
InChI
1S/C22H30O4/c1-14(23)26-13-22(24)12-21-9-5-17-16-7-10-25-18(16)6-8-20(17,2)19(21)4-3-15(22)11-21/h7,10,15,17,19,24H,3-6,8-9,11-13H2,1-2H3
InChI key
PTGGVIKFNQSFBY-UHFFFAOYSA-N
애플리케이션
Cafestol acetate has been used to determine the effects of coffee on heat shock response (HSR).[1]
생화학적/생리학적 작용
Cafestol is a coffee-specific diterpene.[2] It has anti-carcinogenic and anti-inflammatory activities.[3] Cafestol stimulates apoptosis in cells associated with colorectal and renal cancer (Caki cells). It is used to study mechanisms of anti-oxidation related to hydrogen peroxide induced oxidative stress and DNA damage.[2] Cafestol increases the level of glutathione (GSH), by stimulating γ-glutamylcysteine synthetase. It acts as a chemopreventive agent by inducing cytochrome P-450.[3]
기타 정보
Furan-containing diterpene from green coffee beans.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Wolfgang W Huber et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 46(4), 1230-1238 (2007-11-07)
Coffee drinking appears to reduce cancer risk in liver and colon. Such chemoprevention may be caused by the diterpenes kahweol and cafestol (K/C) contained in unfiltered beverage. In animals, K/C treatment inhibited the mutagenicity/tumorigenicity of several carcinogens, likely explicable by
Use of silver nitrate impregnated silica cartridges in the separation of kahweol and cafestol esters by preparative liquid chromatography.
L K Lam et al.
Journal of chromatography, 328, 422-424 (1985-06-28)
Kai-Shan Tao et al.
Medical hypotheses, 71(5), 730-736 (2008-08-15)
Epidemiological studies have found an inverse association between coffee consumption and the risk of liver cancer. Animal data support such a chemopreventive effect of coffee. Substantial research has been devoted to the identification of coffee components that may be responsible
Min Jung Choi et al.
Chemico-biological interactions, 190(2-3), 102-108 (2011-02-22)
Cafestol, one of the major compounds in coffee beans, has been reported for its tumor cell growth inhibitory activity and anti-carcinogenic activity, although the mechanism of action is poorly understood. In the present study, we investigated the effect of cafestol
Agnieszka Potęga et al.
Journal of pharmaceutical analysis, 10(4), 376-384 (2020-09-15)
5-Dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) is a promising antitumor compound developed in our laboratory. A better understanding of its metabolic transformations is still needed to explain the multidirectional mechanism of pharmacological action of triazoloacridinone derivatives at all. Thus, the aim of the current
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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