C0244
CDK1/Cyclin A2, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
동의어(들):
CCN1, CCNA, CDC2, CDC28A, DKFZp686120222, MGC111195
로그인조직 및 계약 가격 보기
크기 선택
10 μG
₩817,887
모든 사진(1)
크기 선택
보기 변경
10 μG
₩817,887
About This Item
UNSPSC 코드:
12352200
NACRES:
NA.32
추천 제품
재조합
expressed in baculovirus infected Sf9 cells
Quality Level
제품 라인
PRECISIO® Kinase
분석
≥70% (SDS-PAGE)
양식
buffered aqueous glycerol solution
특이 활성도
151-205 nmol/min·mg
분자량
CDK1 subunit ~59 kDa
cyclin A2 ~78 kDa
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... CCNA2(890) , CDK1(983)
생화학적/생리학적 작용
CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
물리적 형태
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
법적 정보
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Manas Seal et al.
The journal of physical chemistry. B, 125(47), 12947-12957 (2021-11-18)
Knowledge about the structural and dynamic properties of proteins that form membrane-less organelles in cells via liquid-liquid phase separation (LLPS) is required for understanding the process at a molecular level. We used spin labeling and electron paramagnetic resonance (EPR) spectroscopy
A C Rigas et al.
Oncogene, 26(55), 7611-7619 (2007-06-30)
Antiandrogens are initially effective in controlling prostate cancer (CaP), the second most common cancer in men, but resistance, associated with the loss of androgen-regulated cell cycle control, is a major problem. At present there is no effective treatment for androgen-independent
Annelies Vantieghem et al.
The Journal of biological chemistry, 277(40), 37718-37731 (2002-07-09)
The role of Bcl-2 in photodynamic therapy (PDT) is controversial, and some photosensitizers have been shown to induce Bcl-2 degradation with loss of its protective function. Hypericin is a naturally occurring photosensitizer with promising properties for the PDT of cancer.
Carine Bossard et al.
PloS one, 7(9), e44787-e44787 (2012-09-13)
Ovarian cancer is the gynecological cancer exhibiting the highest morbidity and improvement of treatments is still required. Previous studies have shown that Estrogen-receptor beta (ERβ) levels decreased along with ovarian carcinogenesis. Here, we present evidence that reintroduction of ERβ in
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
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