추천 제품
분석
≥98% (HPLC)
양식
solid
색상
yellow
solubility
DMSO: >20 mg/mL
저장 온도
2-8°C
SMILES string
Oc1cc(F)ccc1-c2ccc(\C=C3\SC(=O)NC3=O)o2
InChI
1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6+
InChI key
OYYVWNDMOQPMGE-WUXMJOGZSA-N
생화학적/생리학적 작용
AS-252424 is a potent and selective phosphoinositide 3-kinase PI3Kγ inhibitor with IC50 = 30 nM in a mouse model.
AS-252424 is a potent and selective phosphoinositide 3-kinase PI3Kγ inhibitor.
특징 및 장점
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Enrico Conte et al.
PloS one, 6(10), e24663-e24663 (2011-10-11)
Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disease characterized by an accumulation of fibroblasts and myofibroblasts in the alveolar wall. Even though the pathogenesis of this fatal disorder remains unclear, transforming growth factor-β (TGF-β)-induced differentiation and proliferation of myofibroblasts
Rabea Müller et al.
Frontiers in cellular neuroscience, 7, 24-24 (2013-03-19)
In cells cultured from neocortex of newborn rats, phosphoinositide-3-kinases of class I regulate the DNA synthesis in a subgroup of astroglial cells. We have studied the location of these cells as well as the kinase isoforms which facilitate the S
Vincent Pomel et al.
Journal of medicinal chemistry, 49(13), 3857-3871 (2006-06-23)
Class I phosphoinositide 3-kinases (PI3Ks), in particular PI3Kgamma, have become attractive drug targets for inflammatory and autoimmune diseases. Here, we disclose a novel series of furan-2-ylmethylene thiazolidinediones as selective, ATP-competitive PI3Kgamma inhibitors. Structure-based design and X-ray crystallography of complexes formed
Kaoru Hazeki et al.
PloS one, 6(10), e26836-e26836 (2011-11-05)
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG) stimulate innate immune responses. Phosphoinositide 3-kinase (PI3K) has been implicated in CpG-induced immune activation; however, its precise role has not yet been clarified. CpG-induced production of IL-10 was dramatically increased in macrophages deficient
Olga Ksionda et al.
PloS one, 13(5), e0193849-e0193849 (2018-05-26)
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer. Poly-chemotherapy with cytotoxic and genotoxic drugs causes substantial toxicity and more specific therapies targeting the underlying molecular lesions are highly desired. Perturbed Ras signaling is prevalent in T-ALL and
문서
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
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