추천 제품
Quality Level
분석
≥98% (HPLC)
양식
oil
색상
yellow
solubility
DMSO: >10 mg/mL
배송 상태
wet ice
저장 온도
−20°C
SMILES string
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCCc1c[nH]c2ccc(O)cc12
InChI
1S/C30H42N2O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-30(34)31-23-22-26-25-32-29-21-20-27(33)24-28(26)29/h6-7,9-10,12-13,15-16,20-21,24-25,32-33H,2-5,8,11,14,17-19,22-23H2,1H3,(H,31,34)/b7-6-,10-9-,13-12-,16-15-
InChI key
QJDNHGXNNRLIGA-DOFZRALJSA-N
애플리케이션
Arachidonoylserotonin is a fatty acid amide hydrolase (FAAH) inhibitor and transient receptor potential vanilloid-type I (TRPV1) antagonist. Both FAAH and TRPV1 are targets for chronic pain treatment. Arachidonoylserotonin has been used in a study to determine the involvement of endovanilloids in the cortical plastic changes associated with peripheral nerve injury.
생화학적/생리학적 작용
Arachidonoylserotonin is a Fatty Acid Amide Hydrolase (FAAH) Inhibitor and Transient Receptor Potential Vanilloid-Type I (TRPV1) Antagonist.
Arachidonoylserotonin is a Fatty Acid Amide Hydrolase (FAAH) Inhibitor and Transient Receptor Potential Vanilloid-Type I (TRPV1) Antagonist. FAAH and TRPV1 are targets for chronic pain treatment. Arachidonylserotonin is a dual target agent and is analgesic in rodents.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
D De Filippis et al.
Pharmacological research, 61(4), 321-328 (2009-11-26)
The endocannabinoids anandamide and 2-arachidonoylglycerol, and the anandamide-congener, palmitoylethanolamide, are all substrates for the enzyme fatty acid amide hydrolase, and are endowed with anti-inflammatory actions exerted via cannabinoid receptors or, in the case of palmitoylethanolamide, also via other targets. We
The blockade of the transient receptor potential vanilloid type 1 and fatty acid amide hydrolase decreases symptoms and central sequelae in the medial prefrontal cortex of neuropathic rats
de Novellis, V., et al.
Molecular Pain, 17, 7-7 (2011)
Barbara Costa et al.
Pharmacological research, 61(6), 537-546 (2010-02-09)
Given that the pharmacological or genetic inactivation of fatty acid amide hydrolase (FAAH) counteracts pain and inflammation, and on the basis of the established involvement of transient receptor potential vanilloid type-1 (TRPV1) channels in inflammatory pain, we tested the capability
Ya Wang et al.
Biochimica et biophysica acta, 1862(9), 823-831 (2017-05-21)
Fatty acid amides (FAAs), conjugates of fatty acids with ethanolamine, mono-amine neurotransmitters or amino acids are a class of molecules that display diverse functional roles in different cells and tissues. Recently we reported that one of the serotonin-fatty acid conjugates
Luciano R Vilela et al.
Basic & clinical pharmacology & toxicology, 115(4), 330-334 (2014-03-29)
Selective blockade of anandamide hydrolysis, through the inhibition of the FAAH enzyme, has anticonvulsant effects, which are mediated by CB1 receptors. Anandamide, however, also activates TRPV1 channels, generally with an opposite outcome on neuronal modulation. Thus, we suggested that the
문서
We offer many products related to transient receptor potential channels for your research needs.
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