A6933

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

≥97% (HPLC), powder

• 동의어(들): Ac-QKLVFF-NH₂, amyloid blocker
• 실험식(Hill 표기법): C₄₂H₆₃N₉O₈
• CAS Number: 189064-06-0
• Molecular Weight: 822.01
• MDL number: MFCD17215285
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329770908
• NACRES: NA.32

속성

• Quality Level: 200
• 분석: ≥97% (HPLC)
• 양식: powder
• 색상: white
• UniProt 수납 번호: P05067
• 저장 온도: −20°C
• SMILES string: CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(N)=O
• InChI: 1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1
• InChI key: DDXTVYDSGCHGAN-PITCCTKHSA-N
• 유전자 정보: human ... APP(351)

설명

Amino Acid Sequence

Ac-Gln-Lys-Leu-Val-Phe-Phe-NH2

생화학적/생리학적 작용

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)