A3227

Ala-Tyr-Pro-Gly-Lys-Phe-NH₂ trifluoroacetate salt

≥98% (HPLC), lyophilized powder, PAR4 agonist

• 동의어(들): AYPGKF-NH₂, PAR4-AP
• 실험식(Hill 표기법): C₃₄H₄₈N₈O₇ · xC₂HF₃O₂
• CAS Number: 1228078-65-6
• Molecular Weight: 680.79 (free base basis)
• MDL number: MFCD04974484
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329770819
• NACRES: NA.77

속성

• 제품명: Ala-Tyr-Pro-Gly-Lys-Phe-NH₂ trifluoroacetate salt, ≥98% (HPLC), lyophilized powder
• 분석: ≥98% (HPLC)
• 양식: lyophilized powder
• 색상: white
• solubility: H₂O: >10 mg/mL
• 저장 온도: −20°C
• SMILES string: OC(=O)C(F)(F)F.C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCCC2C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc3ccccc3)C(N)=O
• InChI: 1S/C34H48N8O7.C2HF3O2/c1-21(36)31(46)41-27(19-23-12-14-24(43)15-13-23)34(49)42-17-7-11-28(42)33(48)38-20-29(44)39-25(10-5-6-16-35)32(47)40-26(30(37)45)18-22-8-3-2-4-9-22;3-2(4,5)1(6)7/h2-4,8-9,12-15,21,25-28,43H,5-7,10-11,16-20,35-36H2,1H3,(H2,37,45)(H,38,48)(H,39,44)(H,40,47)(H,41,46);(H,6,7)/t21-,25-,26-,27-,28-;/m0./s1
• InChI key: BGPJLFVICWHITH-HKJXYENISA-N

설명

Amino Acid Sequence

Ala-Tyr-Pro-Gly-Lys-Phe-NH2

일반 설명

Ala-Tyr-Pro-Gly-Lys-Phe-NH₂ (AYPGKF- NH₂) is a selective, specific proteinase-activated receptor 4 (PAR4) agonist peptide. PAR4 is a G-protein-coupled receptor that is expressed on the surface of human platelets and is involved in the thrombin signaling pathway. Cleavage of PAR4 by the protease thrombin stimulates the receptor and results in signaling of platelet aggregation.

애플리케이션

4-Androsten-11β-ol-3,17-dione has been used in platelet aggregation.[1]

AYPGKF- NH₂ may be used for probing PAR4 signaling in culture systems and in platelets.

생화학적/생리학적 작용

AYPGK is a ligand for the PAR4 receptor; binding results in activation of PAR4. AYPGK stimulates platelet aggregation in vitro (EC50 =15 μM) via PAR4. In human platelets treated with the PAR4 agonist, AYPGKF stimulates the production of thromboxane, a potent agent for platelet-aggregation.[2] Additionally, AYPGKF mediates the thrombin-induced release of endostatin from rat platelets.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)