A2580

Angiotensin Converting Enzyme from porcine kidney

lyophilized powder, ≥10 units/mg protein (Bradford)

• 동의어(들): ACE, Peptidyl-dipeptidase A
• CAS Number: 9015-82-1
• 효소 위원회 번호: 3.4.15.1 (BRENDA, IUBMB)
• MDL number: MFCD00130325
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 양식: lyophilized powder
• Quality Level: 200
• 특이 활성도: ≥10 units/mg protein (Bradford)
• UniProt 수납 번호: A0A480IQM9
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: pig ... ACE(613133)

설명

일반 설명

ACE is a monomer with molecular weight of ~170 kDa
pH range for activity: 7-8.5
Temperature optimum: 37 °C
Zinc is required for activity
Inhibitors: captopril, enalaprilat, lisinopril etc. (1-10 μM)

Angiotensin converting enzyme (ACE) is encoded by the gene, mRNA-decapping enzyme subunit 1 (DCP1).[1] It is a zinc metalloprotease, which belongs to the M2 family.[2]

애플리케이션

Angiotensin converting enzyme from porcine kidney has been used in in vitro angiotensin-converting enzyme (ACE) inhibition assay.[3]

생화학적/생리학적 작용

Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to angiotensin II, which regulates the fluid-electrolyte balance and systemic blood pressure.[1] ACE inhibits the vasodilator, bradykinin.[2] ACE inhibitors are used to treat high blood pressure.[4]

Removes C-terminal dipeptides from susceptible substrates, e.g., angiotensin I and bradykinin.

단위 정의

One unit will produce 1.0 ·μmole of hippuric acid from Hippuryl-His-Leu per min in 50 mM HEPES and 300 mM NaCl at pH 8.3 at 37 °C.

물리적 형태

Lyophilized powder containing Tris buffer salts.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H334
• 예방조치 성명서: P261 - P284 - P501
• Hazard Classifications: Resp. Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)