모든 사진(1)
About This Item
실험식(Hill 표기법):
C14H24N2O7 · 2HCl · 5H2O
CAS Number:
Molecular Weight:
495.35
Beilstein:
5684150
EC Number:
MDL number:
UNSPSC 코드:
51101500
PubChem Substance ID:
추천 제품
생물학적 소스
synthetic
분석
≥98.0% (AT)
양식
solid
색상
white
solubility
H2O: 50 mg/mL, clear, faintly yellow
항생제 활성 스펙트럼
Gram-negative bacteria
Gram-positive bacteria
동작 모드
protein synthesis | interferes
저장 온도
2-8°C
SMILES string
Cl[H].Cl[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H][C@@]12O[C@H](C)CC(=O)[C@]1(O)O[C@]3([H])[C@@H](NC)[C@@H](O)[C@@H](NC)[C@H](O)[C@@]3([H])O2
InChI
1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
InChI key
DCHJOVNPPSBWHK-UXXUFHFZSA-N
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일반 설명
Chemical structure: aminoglycoside
애플리케이션
Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.
주의사항
Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.
제조 메모
Stock solutions should be prepared at 10 mg/mL in water and filter sterilized.
기타 정보
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
D Moazed et al.
Nature, 327(6121), 389-394 (1987-06-04)
Chemical footprinting shows that several classes of antibiotics (streptomycin, tetracycline, spectinomycin, edeine, hygromycin and the neomycins) protect concise sets of highly conserved nucleotides in 16S ribosomal RNA when bound to ribosomes. These findings have strong implications for the mechanism of
Corinna Kehrenberg et al.
Antimicrobial agents and chemotherapy, 51(6), 2244-2246 (2007-03-21)
Pasteurella multocida isolates with high-level spectinomycin resistance in which no adenyltransferase genes could be demonstrated exhibited a C1192G transversion in the 16S rRNA of all six or five of the six rRNA operons and/or two different types of 3-bp deletions
Daniel Criswell et al.
Antimicrobial agents and chemotherapy, 50(2), 445-452 (2006-01-27)
We have isolated and characterized in vitro mutants of the Lyme disease agent Borrelia burgdorferi that are resistant to spectinomycin, kanamycin, gentamicin, or streptomycin, antibiotics that target the small subunit of the ribosome. 16S rRNA mutations A1185G and C1186U, homologous
Nicholas Desnoyer et al.
BMC plant biology, 20(1), 380-380 (2020-08-20)
Glycosylphosphatidylinositol (GPI) addition is one of the several post-translational modifications to proteins that increase their affinity for membranes. In eukaryotes, the GPI transamidase complex (GPI-T) catalyzes the attachment of pre-assembled GPI anchors to GPI-anchored proteins (GAPs) through a transamidation reaction.
Yi-Ywan M Chen et al.
Applied and environmental microbiology, 77(12), 3967-3974 (2011-05-03)
Streptococcus parasanguinis is among the most successful colonizers of the human body. Strain FW213 harbors a 7.0-kb cryptic plasmid, pFW213, with a copy number at 5 to 10 per chromosome. Sequence and functional analyses of pFW213 revealed that the open
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