51060

Guanosine 5′-diphosphate disodium salt

≥90% (HPLC)

• 동의어(들): 5′-GDP-Na₂
• 실험식(Hill 표기법): C₁₀H₁₃N₅Na₂O₁₁P₂
• CAS Number: 7415-69-2
• Molecular Weight: 487.16
• EC Number: 231-026-2
• MDL number: MFCD00084665
• UNSPSC 코드: 41106305
• PubChem Substance ID: 57651304
• NACRES: NA.51

속성

• 생물학적 소스: Porcine brain; microbial (Corynebacterium sp); synthetic
• Quality Level: 100
• 분석: ≥90% (HPLC)
• 양식: powder
• solubility: H₂O: 50 mg/mL, clear, colorless
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: [Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
• InChI key: LTZCGDIGAHOTKN-LGVAUZIVSA-L

설명

일반 설명

Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine.[1] GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.[2]

애플리케이션

Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.

Guanosine 5′-diphosphate disodium salt has been used:

• in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp[3]
• in screening of fluorescence emission of hypocrellin A-zinc complex[4]
• as a component of assay buffers in the autoradiography of mice brain sections[5]

생화학적/생리학적 작용

Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors.[2] Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein [6]. G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP.[7] GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).[3]

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)