484R-1

PRAME (EP461) Rabbit Monoclonal Primary Antibody

• 동의어(들): Preferentially-expressed Antigen in Melanoma
• UNSPSC 코드: 12352203

속성

• 생물학적 소스: rabbit
• Quality Level: 100; 500
• 결합: unconjugated
• 항체 형태: culture supernatant
• 항체 생산 유형: primary antibodies
• 클론: EP461, monoclonal
• 설명: For In Vitro Diagnostic Use in Select Regions
• 양식: buffered aqueous solution
• 종 반응성: human
• 포장: vial of 0.1 mL concentrate (484R-14); vial of 0.1 mL concentrate Research Use Only (484R-14-RUO); vial of 0.5 mL concentrate (484R-15); vial of 1.0 mL concentrate (484R-16); vial of 1.0 mL concentrate Research Use Only (484R-16-RUO); vial of 1.0 mL pre-dilute Research Use Only (484R-17-RUO); vial of 1.0 mL pre-dilute ready-to-use (484R-17); vial of 25.0 mL pre-dilute ready-to-use Research Use Only (484R-10-RUO); vial of 25.0 mL pre-dilute ready-to-use (484R-10); vial of 7.0 mL pre-dilute ready-to-use (484R-18); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (484R-18-RUO)
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)
• 동형: IgG
• 제어: melanoma
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 시각화: nuclear

설명

일반 설명

PRAME (PReferentially-expressed Antigen in MElanoma) is a gene encoded on the 22q11-22 chromosomal sequence and encodes a 509 amino acid residue protein.¹ PRAME is a melanoma antigen that is preferentially expressed in tumors and is recognized by cytotoxic T lymphocytes.^2,3 PRAME can be used to distinguish between malignant melanoma cells and nevus cells,⁴ and therefore may be useful for diagnostic purposes to support a suspected case of melanoma. PRAME is considered a cancer-testis antigen (CTA)⁵ and is not strongly expressed in most other normal tissues. PRAME is positively expressed in about half of uveal melanomas,⁶ and the majority of mucosal melanomas.⁷

품질

• United States - IVD
• Canada - RUO
• European Union - IVD
• Japan - RUO

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and < 0.1% Sodium Azide.

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기타 정보

For Technical Service please contact: 800-665-7284 or email: [email protected]

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable