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Merck
모든 사진(3)

주요 문서

462R-1

Sigma-Aldrich

SF-1 (EP434) Rabbit Monoclonal Primary Antibody

동의어(들):

Steroidogenic Factor-1

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About This Item

UNSPSC 코드:
12352203
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생물학적 소스

rabbit

Quality Level

100
500

결합

unconjugated

항체 형태

culture supernatant

항체 생산 유형

primary antibodies

클론

EP434, monoclonal

설명

For In Vitro Diagnostic Use in Select Regions

양식

buffered aqueous solution

종 반응성

human

포장

vial of 0.1 mL concentrate (462R-14)
vial of 0.1 mL concentrate Research Use Only (462R-14-RUO)
vial of 0.5 mL concentrate (462R-15)
vial of 1.0 mL concentrate (462R-16)
vial of 1.0 mL concentrate Research Use Only (462R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (462R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (462R-17)
vial of 7.0 mL pre-dilute ready-to-use (462R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (462R-18-RUO)

제조업체/상표

Cell Marque®

기술

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

동형

IgG

제어

adrenocortical carcionma, granulosa cell tumor, testis

배송 상태

wet ice

저장 온도

2-8°C

시각화

nuclear

유전자 정보

human ... SF1(7536)

일반 설명

As both a nuclear receptor and nuclear transcription factor, Steroidogenic factor-1 (SF-1) serves as an important modulator of steroidogenesis.[1][2] It has been demonstrated that SF-1 serves as a “master regulator” in varying facets of development and function in both reproductive and adrenal tissues.[1] Immunohistochemical detection of SF-1 in testicular tissue may provide value for distinguishing sex-cord stromal tumors, including Leydig cell, Sertoli cell and granulosa cell neoplasms, from other tumors.[2][3] In addition, SF-1 detection may have utility in distinguishing primary adrenal cortical lesions from their histologic mimics such as renal clear cell carcinoma.[4]

품질


IVD

IVD

IVD

RUO

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

제조 메모

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기타 정보

For Technical Service please contact: 800-665-7284 or email: [email protected]

법적 정보

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2


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문서 라이브러리 방문

Ranna El-Khairi et al.
Seminars in reproductive medicine, 30(5), 374-381 (2012-10-10)
Steroidogenic factor-1 (SF-1) (Ad4BP, NR5A1) is a nuclear receptor that plays a key role in adrenal and reproductive development and function. Deletion of the gene encoding Sf-1 (Nr5a1) in mice results in severe developmental defects of the adrenal gland and
Ankur R Sangoi et al.
The American journal of surgical pathology, 35(5), 678-686 (2011-04-15)
The diagnosis of metastatic clear cell renal cell carcinoma (CC-RCC) can be difficult because of its morphologic heterogeneity and the increasing use of small image-guided biopsies that yield scant diagnostic material. This is further complicated by the degree of morphologic
Chengquan Zhao et al.
The American journal of surgical pathology, 33(3), 354-366 (2008-11-27)
Different immunohistochemical sex cord-stromal markers have been previously studied in various types of ovarian sex cord-stromal tumors; however, the sensitivity for sex cord-stromal lineage may vary between markers, and some markers may not be as sensitive in some types of
Ankur R Sangoi et al.
Applied immunohistochemistry & molecular morphology : AIMM, 21(4), 318-321 (2012-11-21)
Differentiating testicular germ cell tumors from sex-cord stromal tumors can be difficult in certain cases because of overlapping morphologic features and/or an absence of clinically apparent hormonal symptoms. Immunohistochemistry may be needed as an ancillary diagnostic tool in this differential

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