추천 제품
![[Ir(dFOMeppy)2(dtbbpy)]PF6 ≥95%](/deepweb/assets/sigmaaldrich/product/structures/322/695/c976a02b-e0ec-4b5e-9a54-5324bd63c032/640/c976a02b-e0ec-4b5e-9a54-5324bd63c032.png)
생물학적 소스
mouse
Quality Level
100
500
결합
unconjugated
항체 형태
ascites fluid
항체 생산 유형
primary antibodies
클론
5H6, monoclonal
설명
(For In Vitro Diagnostic Use in Select Regions (See Chart))
양식
buffered aqueous solution
종 반응성
human
포장
vial of 0.1 mL concentrate (424M-14)
vial of 0.5 mL concentrate (424M-15)
bottle of 1.0 mL predilute (424M-17)
vial of 1.0 mL concentrate (424M-16)
bottle of 7.0 mL predilute (424M-18)
제조업체/상표
Cell Marque®
기술
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
동형
IgG2aκ
제어
Wilms’ tumor
배송 상태
wet ice
저장 온도
2-8°C
시각화
nuclear
유전자 정보
human ... CITED1(4435)
일반 설명
CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.1-4 It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.3 Wilms′ tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.1 CITED1 expression has been shown to persist in blastemal cell populations of human WT.1,2 In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.1-4 It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.1 CITED1 has been detected in 86.8% of WT Cases.2
품질
 IVD |  IVD |  IVD |  RUO |
결합
CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
물리적 형태
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
제조 메모
Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.
기타 정보
For Technical Service please contact: 800-665-7284 or email: [email protected]
법적 정보
Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany
적합한 제품을 찾을 수 없으신가요?
당사의 제품 선택기 도구.을(를) 시도해 보세요.
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Harold N Lovvorn et al.
Neoplasia (New York, N.Y.), 9(7), 589-600 (2007-08-22)
Wilms' tumors, or nephroblastomas, are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed metanephric mesenchyme within embryonic kidneys. We have previously shown that the transcriptional regulator CITED1 (CBP/p300-interacting transactivators
Andrew J Murphy et al.
Journal of pediatric surgery, 47(6), 1239-1249 (2012-06-19)
SIX2 and CITED1 are transcriptional regulators that specify self-renewing nephronic progenitor cells of the embryonic kidney. We hypothesized that SIX2, which promotes and maintains this stem cell population, and CITED1 remain active in Wilms' tumor (WT). To evaluate expression domains
Scott Boyle et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 236(8), 2321-2330 (2007-07-07)
Early kidney development in mammals is characterized by reciprocal tissue interaction between the ureteric bud and the metanephric mesenchyme. The coordinated response to this interaction is regulated largely at the transcriptional level. Here, we investigate the expression and function of
활성 필터
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.
