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Merck
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14370

Sigma-Aldrich

Bilirubin

purum, ≥95.0% (UV)

동의어(들):

Bile pigment, Hemetoidin

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크기 선택

250 MG
₩203,406
1 G
₩516,940
5 G
₩1,603,497

₩203,406

출고 가능일2025년 4월 11일세부사항

벌크 견적 요청
모든 사진(1)

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보기 변경
250 MG
₩203,406
1 G
₩516,940
5 G
₩1,603,497

About This Item

실험식(Hill 표기법):
C33H36N4O6
CAS Number:
635-65-4
Molecular Weight:
584.66
Beilstein:
74376
EC Number:
211-239-7
MDL number:
MFCD00005499
UNSPSC 코드:
12352202
PubChem Substance ID:
57647150
NACRES:
NA.25

₩203,406

출고 가능일2025년 4월 11일세부사항

벌크 견적 요청

grade

purum

분석

≥95.0% (UV)

양식

powder

무기 잔류물

≤0.5%

SMILES string

CC1=C(C=C)\C(NC1=O)=C\c2[nH]c(Cc3[nH]c(\C=C4/NC(=O)C(C=C)=C4C)c(C)c3CCC(O)=O)c(CCC(O)=O)c2C

InChI

1S/C33H36N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h7-8,13-14,34-35H,1-2,9-12,15H2,3-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b26-13-,27-14-

InChI key

BPYKTIZUTYGOLE-IFADSCNNSA-N

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관련 카테고리

일반 설명

Bilirubin, a heme catabolism end-product is produced by the reduction of its metabolic precursor biliverdin by the action of enzyme biliverdin reductase.[1]

애플리케이션

Bilirubin has been used as an interfering substance for in vitro interference and stability tests for myoglobin, creatine kinase-MB (CK-MB), and troponin-I[2]. It has also been used as an interfering agent to test the effectiveness of the Heparin Red kit in the detection of various heparins.[3]

생화학적/생리학적 작용

Bilirubin is an active oxidative DNA cleaving agent as well as an effective antioxidant agent, a hydroxyl radical quencher.[1] This bile pigment has both antioxidant and toxic properties.[1] It is a natural inhibitor of vascular smooth muscle cell proliferation (VSMCs).[4] It displays anti-inflammatory and anti-proliferative properties when used as a therapeutic agent in lung/vascular diseases.[5][6] Serum bilirubin concentration slightly above the normal levels have shown a lesser incidence of heart disease.[7] It is a potential therapeutic agent in heart transplantation and T-cell mediated immune disorders.[7]
Well over 99% of total bilirubin is transported as a conjugate with albumin. Abnormally high levels of bilirubin can cause severe neurological damage, but mildly elevated levels are linked to protection from oxidative stress.

분석 메모

λmax. ∼453 nm, mol. absorption >56100 (chloroform)

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
BCCL6435
BCCJ8864
BCCL1458
BCCH1649
BCCF8504

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문서 라이브러리 방문

Kenichiro Yamashita et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(6), 765-767 (2004-02-24)
Biliverdin, a product of heme oxygenase-1 (HO-1) enzymatic action, is converted into bilirubin, which has been considered a waste product in the past. We now show that administration of biliverdin has a salutary effect in organ transplantation. A brief course
Yen-Wen Wu et al.
Acta Cardiologica Sinica, 36(6), 649-659 (2020-11-26)
The rapid diagnosis of acute myocardial infarction (AMI) is a clinical and operational priority in emergency departments. Serial serum levels of cardiac biomarkers play a crucial role in the evaluation of patients presenting with acute chest pain, so that an
Stefan W Ryter et al.
American journal of respiratory cell and molecular biology, 36(2), 175-182 (2006-09-19)
Heme oxygenase (HO)-1, an inducible, low-molecular-weight stress protein, confers cellular and tissue protection in multiple models of injury and disease, including oxidative or inflammatory lung injury, ischemia/reperfusion (I/R) injuries, and vascular injury/disease. The tissue protection provided by HO-1 potentially relates
U Warttinger et al.
Analytical and bioanalytical chemistry, 408(28), 8241-8251 (2016-10-22)
Heparins are widely used anticoagulant drugs. The current monitoring practice for heparin in plasma, such as the chromogenic anti-factor Xa assay, relies on heparin-triggered activation of antithrombin, an inhibitor of coagulation proteases. Such assays are not applicable to the detection
Robert Ollinger et al.
Cell cycle (Georgetown, Tex.), 6(1), 39-43 (2007-01-25)
We have recently shown that the natural bile pigment bilirubin has antiproliferative effects on vascular smooth muscle cells (VSMCs). Bilirubin is the end product of heme catabolism mediated by heme oxygenases and has for decades been considered a toxic waste
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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 답변

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 답변

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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