125M-1

CD25 (4C9) Mouse Monoclonal Antibody

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100; 500
• 결합: unconjugated
• 항체 형태: culture supernatant
• 항체 생산 유형: primary antibodies
• 클론: 4C9, monoclonal
• 설명: For In Vitro Diagnostic Use in Select Regions (See Chart)
• 형태: buffered aqueous solution
• 종 반응성: human
• 포장: vial of 0.1 mL concentrate (125M-14); vial of 0.5 mL concentrate (125M-15); bottle of 1.0 mL predilute (125M-17); vial of 1.0 mL concentrate (125M-16); bottle of 7.0 mL predilute (125M-18)
• 제조업체/상표: Cell Marque^™
• 기술: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
• 동형: IgG2b
• 제어: lesions of mastocytosis
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 시각화: cytoplasmic, membranous
• 유전자 정보: human ... IL2RA(3559)

설명

일반 설명

According to the World Health Organization classification system, the major diagnostic criterion for bone marrow involvement by Systemic Mastocytosis (SM) is the presence of dense aggregates (>15 cells) of mast cells. Expression of CD25, a low-affinity receptor for interleukin-2 (IL-2), is a reliable diagnostic tool for distinguishing neoplastic mast cell aggregates from reactive proliferations, and has therefore recently become a minor criterion for the diagnosis of SM. Hahn et al. demonstrated that aberrant staining of Mast cell clusters by anti-CD25 antibody in GI biopsies was essentially diagnostic of SM. Anti-CD25 antibody has also been useful in identifying mast cells in skin biopsies in the setting of Urticaria Pigmentosa, which is predictive of Systemic Mastocytosis. Quantitation of regulatory T cells (Treg) in the setting of hepatocellular carcinoma has been used as an independent predictive factor of tumor recurrence after hepatic resection for HCC. Also, the percentage of tumor-infiltrating CD25+FOXP3+ regulatory T cells among tumor cells, inside tumor parenchyma and at its periphery, is significantly higher in recurrent cutaneous melanoma than in non-recurrent melanoma.

품질

IVD

IVD

IVD

RUO

결합

CD25 Positive Control Slides, Product No. 125S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

물리적 형태

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

제조 메모

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

기타 정보

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

법적 정보

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable