11702

Bacitracin

from Bacillus licheniformis, ≥65 IU/mg

• 동의어(들): Altracin, Bacitracin A
• 실험식(Hill 표기법): C₆₆H₁₀₃N₁₇O₁₆S
• CAS Number: 1405-87-4
• Molecular Weight: 1422.69
• EC Number: 215-786-2
• MDL number: MFCD00062640
• UNSPSC 코드: 51282002
• PubChem Substance ID: 57646949
• NACRES: NA.85

속성

• 생물학적 소스: Bacillus licheniformis
• Quality Level: 200
• 양식: powder
• 특이 활성도: ≥65 IU/mg
• 색상: white to pale buff
• 항생제 활성 스펙트럼: Gram-positive bacteria
• 동작 모드: cell wall synthesis | interferes
• 저장 온도: 2-8°C
• SMILES string: [H]N1[C@@H](Cc2cnc[nH]2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)C3CSC(=N3)C(N)C(C)CC)[C@@H](C)CC)C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](Cc4ccccc4)C1=O
• InChI: 1S/C66H103N17O16S/c1-9-35(6)52(69)66-81-48(32-100-66)63(97)76-43(26-34(4)5)59(93)74-42(22-23-50(85)86)58(92)83-53(36(7)10-2)64(98)75-40-20-15-16-25-71-55(89)46(29-49(68)84)78-62(96)47(30-51(87)88)79-61(95)45(28-39-31-70-33-72-39)77-60(94)44(27-38-18-13-12-14-19-38)80-65(99)54(37(8)11-3)82-57(91)41(21-17-24-67)73-56(40)90/h12-14,18-19,31,33-37,40-48,52-54H,9-11,15-17,20-30,32,67,69H2,1-8H3,(H2,68,84)(H,70,72)(H,71,89)(H,73,90)(H,74,93)(H,75,98)(H,76,97)(H,77,94)(H,78,96)(H,79,95)(H,80,99)(H,82,91)(H,83,92)(H,85,86)(H,87,88)/t35?,36-,37-,40-,41+,42+,43-,44+,45-,46-,47+,48?,52?,53-,54-/m0/s1
• InChI key: CLKOFPXJLQSYAH-RNHDWVCBSA-N

설명

일반 설명

Chemical structure: peptide

애플리케이션

Bacitracin is used to study disruption of bacterial cell wall synthesis at the level of peptidoglycan biosynthesis and isoprenyl metabolism. It is also used to study the biosynthesis of sterols and squalene.
Bacitracin has been used:

• as a protease inhibitor[1]
• as a control antibiotic[2]
• for the calibration in size exclusion chromatography[3]

생화학적/생리학적 작용

Bacitracin has been shown to decrease vancomycin-resistant Enterococcus faecium population in intestine.[4]

Bacitracin is a peptide antibiotic.
Antimicrobial spectrum: Gram-positive bacteria.
Mode of Action: Inhibits bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate.

포장

5G, 25 G

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)