A7085

Acetaminophen

BioXtra, ≥99.0%

• 동의어(들): 4′-Hydroxyacetanilide, 4-Acetamidophenol, N-(4-Hydroxyphenyl)acetamide, N-Acetyl-4-aminophenol, APAP, Paracetamol
• Linear Formula: CH₃CONHC₆H₄OH
• CAS Number: 103-90-2
• Molecular Weight: 151.16
• Beilstein: 2208089
• EC Number: 203-157-5
• MDL number: MFCD00002328
• UNSPSC 코드: 12352111
• PubChem Substance ID: 24891173
• NACRES: NA.25
• 양식: powder
• 분석: ≥99.0%

속성

• 제품 라인: BioXtra
• Quality Level: 200
• 분석: ≥99.0%
• 양식: powder
• 불순물: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• 무기 잔류물: ≤0.1%
• mp: 168-172 °C (lit.)
• solubility: ethanol: 0.5 M, clear, colorless
• 음이온 미량물: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• 양이온 미량물: Al: ≤0.0005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• SMILES string: CC(=O)Nc1ccc(O)cc1
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
• InChI key: RZVAJINKPMORJF-UHFFFAOYSA-N
• 유전자 정보: human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

설명

일반 설명

Acetaminophen or paracetamol is an analgesic and antipyretic.[1] It is however a weak non opioid analgesic.[2]

애플리케이션

Acetaminophen has been used:

• as an anti-inflammatory drug to test its effect in lipid peroxidation in marine mussels[3]
• to test its effect on neurite outgrowth in gamma-aminobutyric acid-ergic and glutamatergic neurons[4]
• as a hepatocellular injury inducing agent in mice[5]

Analgesic.

생화학적/생리학적 작용

Acetaminophen or paracetamol is an inhibitor of prostaglandin synthesis. It is complexed with arachidonic acid in central nervous system resulting in the formation of N-arachidonoylphentolamine, which is essential for the activation of cannabinoid receptor.[1] Acetaminophen is metabolized to toxic N-acetyl-p-benzoquinone imine. Paracetamol is prescribed for osteoarthritis pain and inhibits cyclooxygenase 1 and 2 activities.[6] It is metabolized by the cytochrome P450 enzymes in liver and is implicated in liver toxicity.[2]

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): 364.3 °F - Pensky-Martens closed cup
• Flash Point (°C): 184.6 °C - Pensky-Martens closed cup
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves