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Merck
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HCYTABG-17K

Millipore

MILLIPLEX® Human Cytokine Autoantibody Expanded IgG Kit

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About This Item

UNSPSC 코드:
12161503
NACRES:
NA.84
To order a Milliplex® kit, please search for your analyte of interest.
Design And Price Your Kit

종 반응성

human

Quality Level

200

제조업체/상표

Milliplex®

기술

multiplexing: suitable

검출 방법

fluorometric (Luminex® xMAP®)

저장 온도

2-8°C

일반 설명

Anti-cytokine antibodies occur frequently and are present in healthy individuals and patients with acquired immunodeficiency and autoimmune diseases. Cytokines offering protection against microbes can be targeted by cytokine autoantibodies, leading to life-threatening infections. Some infections associated with anti-cytokine antibodies include M. tuberculosis, Salmonella, S. aureus. E. coli, Histoplasma, and more. The presence of cytokine autoantibodies in autoimmune disease can influence disease severity and activity. These autoimmune diseases may include systemic lupus erythematosus, multiple sclerosis, Sjögren’s syndrome, rheumatoid arthritis, and acute respiratory distress syndrome. Measuring cytokine autoantibodies may be useful for disease monitoring and efficacy of treatment.The MILLIPLEX® Human Cytokine Autoantibody Expanded IgG Magnetic Bead Panel is a 23-plex kit to be used for the simultaneous detection of any or all of the listed analytes in serum and plasma samples.

애플리케이션

The MILLIPLEX® Human Cytokine Autoantibody Expanded IgG Panel is a bead-based qualitative assay based on the Luminex® xMAP® technology, which enables the simultaneous analysis of cytokine autoantibodies in human serum and plasma samples.

Analytes available:
Anti-BAFF, Anti-G-CSF, Anti-IFNβ, Anti-IFNγ, Anti-IL-1α, Anti-IL-6, Anti IL 8, Anti-IL-10, Anti-IL-12p40, Anti-IL-15, Anti-IL-17A, Anti-IL-17F, Anti-IL-18, Anti-IL-22, Anti-TNFα, Anti-IFNα2, Anti-GM-CSF, Anti-IL-2, Anti-IL-3, Anti-IL-4, Anti-Osteopontin, Anti-PF4, and Anti-IFNω

Panel Type: MAGNETIC Immune Response
Cross Reactivity: There was no or negligible cross-reactivity between the antibodies for an analyte and any of the other analytes in this panel.

Research Category: Inflammation & ImmunologyResearch Sub-Category: Inflammation & Autoimmune Mechanisms;Inflammation

특징 및 장점

Design your multiplex kit by choosing available analytes within this panel.

법적 정보

Luminex is a registered trademark of Luminex Corp
MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany
xMAP is a registered trademark of Luminex Corp

픽토그램

Exclamation markEnvironment
GHS07,GHS09

신호어

Warning

유해 및 위험 성명서

H317,H319,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Irrit. 2 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

질문

1–2 / 2 질문  

  1. Could you please confirm whether the Human Cytokine Autoantibody IgG Panel PE-IgG Conjugate provided with the HCYTABG-17K kit recognizes all IgG subtypes? If so, could you indicate if it recognizes the FC region or H+L?

    1 답변

    1. The Human Cytokine Autoantibody IgG Panel PE-IgG Conjugate provided with the HCYTABG-17K kit measures all IgG isotypes, and its detection is IgG Fc-specific.

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  2. Does the IgG-PE detection conjugate detect all isoforms of IgG?

    1 답변

    1. The mean proportions of IgG subclasses in normal adult serum are as follows: IgG1: 60%, IgG2: 32%, IgG3: 4%, and IgG4: 4%. The conjugate has been tested directly with IgG1, IgG3, and IgG4 and was reactive with all three, indicating a high likelihood of reactivity with IgG2 as well. The antibody (polyclonal) was purified from human IgG Fc from human serum, making it likely to be reactive with all four isotypes.

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