추천 제품
생물학적 소스
rabbit
Quality Level
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
정제법
affinity chromatography
종 반응성
mouse
기술
immunoprecipitation (IP): suitable
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
일반 설명
Zinc finger and SCAN domain containing protein 4C (UniProt: Q80VJ6) is encoded by the Zscan4c (also known as Gm397) gene (Gene ID: 245109) in mouse. Zscan4 is an embryonic stem (ES) cell-specific transcription factor required to regulate pluripotency, facilitate telomere elongation, and defy cellular senescence. It is expressed during zygotic genome activation in mouse two-cell embryos. It protects embryos from DNA damage by stabilizing the B-DNA form of microsatellite repeat DNA. It binds to the TGCACAC motif in CA/TG microsatellite repeats and regulates telomere elongation to maintain genomic stability and acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) in undifferentiated ES cells. Dysfunction of Zscan4 during development or in mESCs leads to implantation failure, telomere maintenance defects, and chromosomal rearrangements. (Ref.: Srinivasan, R., et al., (2020), Sci. Adv., 6, eaaz9115)
면역원
KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal half of mouse Zscan4. The immunogen sequence is conserved between Zcsan4 family proteins (Zscan4b, Zscan4C, Zscan4d and Zscan4f).
애플리케이션
Anti-Zscan4, Cat. No. AB4340, is a rabbit polyclonal antibody that detects Zscan4 and is tested for use in Western Blotting.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
품질
Evaluated by Western Blotting in mouse embryonic stem cell (mESCs) lysate. Western Blotting Analysis: A 1:2,000 dilution of this antibody detected Zscan4 in mouse embryonic stem cell (mESCs) lysate.
표적 설명
Target molecular weight ~ 60 kDa observed; 60.0 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
물리적 형태
Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
저장 및 안정성
Recommended storage: +2°C to +8°C.
분석 메모
Control
Embryonic Stem Cell lysates
Embryonic Stem Cell lysates
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Lei Yang et al.
EMBO reports, 21(9), e50054-e50054 (2020-07-28)
Cloned animals generated by somatic cell nuclear transfer (SCNT) have been reported for many years; however, SCNT is extremely inefficient, and zygotic genome activation (ZGA) is required for SCNT-mediated somatic cell reprogramming. To identify candidate factors that facilitate ZGA in
Diego Rodriguez-Terrones et al.
EMBO reports, 21(1), e48354-e48354 (2019-12-19)
Pluripotent stem cells are thought of as a surrogate of early developmental stages that sustain the capacity to generate all cell types in the body, thereby constituting an invaluable tool to address the mechanisms underlying cellular plasticity. In the mouse
Diego Rodriguez-Terrones et al.
Nature genetics, 50(1), 106-119 (2017-12-20)
Unlike pluripotent cells, which generate only embryonic tissues, totipotent cells can generate a full organism, including extra-embryonic tissues. A rare population of cells resembling 2-cell-stage embryos arises in pluripotent embryonic stem (ES) cell cultures. These 2-cell-like cells display molecular features
Ane Iturbide et al.
Nature structural & molecular biology, 28(6), 521-532 (2021-05-29)
Totipotent cells hold enormous potential for regenerative medicine. Thus, the development of cellular models recapitulating totipotent-like features is of paramount importance. Cells resembling the totipotent cells of early embryos arise spontaneously in mouse embryonic stem (ES) cell cultures. Such '2-cell-like-cells'
Oncostatin M Maintains Naïve Pluripotency of mESCs by Tetraploid Embryo Complementation (TEC) Assay.
Xiaoying Ye et al.
Frontiers in cell and developmental biology, 9, 675411-675411 (2021-06-15)
It has been well established that leukemia inhibitory factor (LIF) is essential for maintaining naïve pluripotency of embryonic stem cells (ESCs). Oncostatin M (OSM) is a member of the IL-6 family of cytokines which share gp130 as a receptor subunit
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