8.55061

HMPB-MBHA resin

Novabiochem^®

• 동의어(들): 4-Hydroxymethyl-3-methoxyphenoxybutyric acid MBHA resin
• UNSPSC 코드: 13111023
• NACRES: NA.22

속성

• Quality Level: 200
• 제품 라인: Novabiochem^®
• 형태: beads
• 반응 적합성: reaction type: Fmoc solid-phase peptide synthesis
• 제조업체/상표: Novabiochem^®
• 응용 분야: peptide synthesis
• 작용기: alcohol
• 저장 온도: 2-30°C

설명

일반 설명

This support consists of MBHA resin functionalized with Riniker′s hyperacid-labile 4-hydroxymethyl-3-methoxyphenoxybutyric acid linker ^[1].This hyperacid-sensitive resin is a useful tool for the Fmoc SPPS of protected peptide acid fragments. Attachment of carboxylic acids is normally achieved by DMAP catalyzed esterification with the appropriate symmetrical anhydride, or by using 2,6-dichlorobenzoylchloride/pyridine ^[2] or MSNT/Melm activation ^[3,4,5].Detachment of these functionalities can be effected by treatment with 1-5% TFA in DCM.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

결합

Replaces: 01-64-0036

분석 메모

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly ( styrene - 1% DVB ) 100- 200 mesh

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable