8.55008

Sieber Amide resin

Novabiochem^®

• 동의어(들): Sieber Amide resin, 9-Fmoc-amino-xanthen-3-yloxy-Merrifield resin
• CAS Number: 915706-90-0
• UNSPSC 코드: 12352111
• NACRES: NA.22

속성

• Quality Level: 400
• 제품 라인: Novabiochem^®
• 형태: beads
• 반응 적합성: reaction type: Fmoc solid-phase peptide synthesis
• 제조업체/상표: Novabiochem^®
• 응용 분야: peptide synthesis
• 작용기: amine
• 저장 온도: 2-8°C

설명

일반 설명

A hyper acid-labile resin for the Fmoc SPPS of protected peptide amides via mild 1% TFA cleavage ^[1,2]. The resin can be readily reductively alkylated to provide a support suited to the synthesis of secondary carboxamides ^[3].This resin has also been employed to produce protected peptide fragments in which the C-terminal carboxylic acid group is blocked as a hydroxymethylphenoxy-β-alaninamide ester ^[4] .

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

애플리케이션

• Determining the Hydrophobicity Index of Protected Amino Acids and Common Protecting Groups: Discusses the synthesis of peptide sequences using Sieber Amide resin for its acid-labile properties. (Gavva et al., 2023).
• Smart biomaterials: Surfaces functionalized with proteolytically stable osteoblast-adhesive peptides: Utilizes Sieber Amide resin for surface functionalization techniques in biomaterials. (Zamuner et al., 2017).
• A 99mTc-tricine-HYNIC-labeled peptide targeting the melanocortin-1 receptor for melanoma imaging: Describes the use of Sieber Amide resin in the synthesis of radiolabeled peptides for diagnostic imaging. (Shamshirian et al., 2016).

결합

Replaces: 01-64-0059

분석 메모

Color (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH₂Cl₂): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/g
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable