8.52418

Fmoc-Asp(OBno)-OH

for peptide synthesis, Novabiochem^®

• 동의어(들): Fmoc-Asp(OBno)-OH
• 실험식(Hill 표기법): C₃₂H₄₃NO₆
• Molecular Weight: 537.69
• UNSPSC 코드: 12352209
• NACRES: NA.22

속성

• 제품명: Fmoc-Asp(OBno)-OH, Novabiochem^®
• Quality Level: 200
• 제품 라인: Novabiochem^®
• 양식: powder
• 반응 적합성: reaction type: Fmoc solid-phase peptide synthesis
• 제조업체/상표: Novabiochem^®
• 응용 분야: peptide synthesis
• 작용기: carboxylic acid
• 저장 온도: −20°C (−15°C to −25°C)

설명

일반 설명

An excellent derivative for minimizing aspartimide formation during Fmoc SPPS, including those containing the Asp-Gly sequence. The bulky OBno protecting group offers considerably more protection against the formation of aspartimide-related by-products than the commonly used OtBu and OMpe group.^[1],[2]

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aspartimide Formation in Fmoc SPPS

Literature references:
^[1] R. Behrendt, et al. (2015) J. Pept. Sci., 21, 680.
^[2] R. Behrendt, et al. (2016) J. Pept. Sci., 22, 92.

애플리케이션

Recently, Fmoc-Asp(OBno)-OH has been used in the synthesis of the mini-protein Omomyc, which has been shown to repress MYC-dependent gene transcription.[3],[4]

분석 메모

Color (visual): white to beige
Appearance of substance (visual): powder, chunks or crystals
Identity (IR): passes test
Purity (TLC (018A)): ≥ 95 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

법적 정보

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable