모든 사진(1)

문서

662056

Ubiquitin Aldehyde

Name: Ubiquitin Aldehyde
Brand: MM

≥95% (HPLC), liquid, ubiquitin hydrolase inhibitor, Calbiochem^®

동의어(들):

ubiquitin hydrolase inhibitor

로그인조직 및 계약 가격 보기

모든 사진(1)

About This Item

UNSPSC 코드:

12352200

NACRES:

NA.77

추천 제품

Slide 1 of 10

1 of 10

Sigma-Aldrich

U5382

Ubiquitin human

Sigma-Aldrich

U6253

Ubiquitin from bovine erythrocytes

Sigma-Aldrich

14-811

UbcH5c Conjugating Enzyme, 100 µg

Sigma-Aldrich

07-2130

Anti-Ubiquitin Antibody

Sigma-Aldrich

L6876

Lysozyme from chicken egg white

Sigma-Aldrich

U5507

Ubiquitin human

Sigma-Aldrich

23-030-M

SCF-Fbw7 Protein Complex, Active, 10 µg

Sigma-Aldrich

X100

Triton^™ X-100

Sigma-Aldrich

T8787

Triton^™ X-100

Sigma-Aldrich

P8849

Protease Inhibitor Cocktail

product name

Ubiquitin Aldehyde, Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover.

Quality Level

100

분석

≥95% (HPLC)

형태

liquid

제조업체/상표

Calbiochem^®

저장 조건

OK to freeze

solubility

DMSO: 50 mg/mL
aqueous buffer: soluble

배송 상태

ambient

저장 온도

−20°C

일반 설명

Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease rates of ubiquitin-dependent degradation.

Potent and specific inhibitor of multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover. Useful for stabilizing endogenous or in vitro synthesized ubiquitin-protein conjugates. May also be used to enhance or decrease the rates of ubiquitin-dependent degradation.

생화학적/생리학적 작용

Cell permeable: no

Primary Target
multiple ubiquitin hydrolases involved in pathways of intracellular protein modification and turnover

Product does not compete with ATP.

Reversible: no

Shown to inhibit the activity of Isopeptidase T (Cat. No. 419700) and Ubiquitin C-Terminal Hydrolase (Cat. No. 662090)

포장

Please refer to vial label for lot-specific concentration.

경고

Toxicity: Standard Handling (A)

물리적 형태

In 150 mM HCL.

재구성

Following reconstitution, aliquot and freeze (-20°C).

기타 정보

Melandri, F., et al. 1996. Biochemistry 35, 12893.
Shaeffer, J.R. and Cohen, R.E. 1996. Biochemistry 35, 10886.
Pickart, C.M. and Rose, I.A. 1986. J. Biol. Chem. 261, 10210.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Noncanonical TGF-β signaling leads to FBXO3-mediated degradation of ΔNp63α promoting breast cancer metastasis and poor clinical prognosis.

Mengmeng Niu et al.

PLoS biology, 19(2), e3001113-e3001113 (2021-02-25)

Transforming growth factor-β (TGF-β) signaling plays a critical role in promoting epithelial-to-mesenchymal transition (EMT), cell migration, invasion, and tumor metastasis. ΔNp63α, the major isoform of p63 protein expressed in epithelial cells, is a key transcriptional regulator of cell adhesion program

FBXL2 counteracts Grp94 to destabilize EGFR and inhibit EGFR-driven NSCLC growth.

Mengmeng Niu et al.

Nature communications, 12(1), 5919-5919 (2021-10-13)

Abnormal activation of epidermal growth factor receptor (EGFR) drives non-small cell lung cancer (NSCLC) development. EGFR mutations-mediated resistance to tyrosine-kinase inhibitors (TKIs) is a major hurdle for NSCLC treatment. Here, we show that F-box protein FBXL2 targets EGFR and EGFR

문서

Ubiquitin Aldehyde