584223

Tetrahydrouridine

≥90% (TLC), liquid, Cytidine deaminase inhibitor, Calbiochem^®

• 동의어(들): InSolution Tetrahydrouridine, THU, H4U, 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one, dihydrate
• 실험식(Hill 표기법): C₉H₁₆N₂O₆ · 2H₂O
• CAS Number: 18771-50-1
• Molecular Weight: 284.26
• MDL number: MFCD00063468
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• product name: Tetrahydrouridine, InSolution, ≥90%, competitive inhibitor of cytidine deaminase
• Quality Level: 100
• 분석: ≥90% (TLC)
• 형태: liquid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• 배송 상태: dry ice
• 저장 온도: −70°C
• SMILES string: OC1CCN([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C(N1)=O
• InChI: 1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
• InChI key: UCKYOOZPSJFJIZ-XVKVHKPRSA-N

설명

일반 설명

A potent competitive inhibitor of cytidine deaminase. Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies. The solid form of this compound (Cat. No. 584222) is also available.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
cytidine deaminase

Reversible: yes

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

물리적 형태

A 100 mM (25 mg/879 µL) solution of Tetrahydrouridine (Cat. No. 584222) in H₂O.

재구성

Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.

기타 정보

Yusa, K., et al. 1995. Biochem. Biophys. Res. Commun.206, 486.

Bouffard, D.Y., et al. 1993. Biochem Pharmacol.45, 1857.
Laliberte, J., et al. 1992. Cancer Chemotherap. Pharmacol.30, 7.
Riva, C., et al. 1992. Chemotherapy38, 358.
Yusa, K., et al. 1992. J. Biol. Chem.267, 16848.
Hanze, A.R. 1967. J. Am. Chem. Soc.89, 6720.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable