D3897

2′-Deoxycytidine

≥99% (HPLC)

• 동의어(들): Cytosine deoxyriboside
• 실험식(Hill 표기법): C₉H₁₃N₃O₄
• CAS Number: 951-77-9
• Molecular Weight: 227.22
• Beilstein: 87567
• EC Number: 213-454-1
• MDL number: MFCD00006547
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24893793
• NACRES: NA.51

속성

• 생물학적 소스: synthetic (organic)
• 분석: ≥99% (HPLC)
• 형태: powder
• solubility: water: 50 mg/mL, clear, colorless to very faintly yellow
• 저장 온도: −20°C
• SMILES string: NC1=NC(=O)N(C=C1)[C@H]2C[C@H](O)[C@@H](CO)O2
• InChI: 1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1
• InChI key: CKTSBUTUHBMZGZ-SHYZEUOFSA-N

설명

일반 설명

2′-Deoxycytidine (deoxyC) is one of the deoxynucleosides containing cytosine as the nucleobase. It is found in the blood, feces, and urine.

애플리케이션

2′-Deoxycytidine has been used:

• as a substrate for Trypanosoma brucei cytidine deaminase (TbCDA) to measure its activity
• as a standard in the isolation and quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC–MS)
• to study the role of autophagy in response to oncogenes and DNA replication stress

생화학적/생리학적 작용

2′-Deoxycytidine (deoxyC) forms dCTP upon phosphorylation which is used to synthesis DNA via various DNA polymerases or reverse transcriptases. DeoxyC is the substrate for deoxycytidine deaminase (EC 3.5.4.14) which converts it into 2′-deoxyuridine. DeoxyC is phosphorylated to the nucleotide dCMP by the enzyme deoxycytidine kinase (DCK). DeoxyC serves as a potential head and neck cancer marker.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)