추천 제품
분석
≥97% (HPLC)
Quality Level
양식
solid
효능
34 nM IC50
색상
off-white
solubility
DMSO: 25 mg/mL
methanol: soluble
일반 설명
A negative control for MAP kinase inhibition studies.
A negative control for SB202190 and SB203580 in p38 MAP kinase inhibition studies.
생화학적/생리학적 작용
p38β
재구성
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
R Nath et al.
Cellular & molecular biology letters, 6(2), 173-184 (2001-09-07)
The mitogen-activated protein kinase (MAPK) cascades are thought to be important mediators in the transduction of extracellular signals into cellular responses. The p38 kinase, a member of the MAPK superfamily, is activated by a wide variety of extracellular stimuli and
R Yu et al.
The Journal of biological chemistry, 275(4), 2322-2327 (2000-01-25)
Phase II drug-metabolizing enzymes, such as glutathione S-transferase and quinone reductase, play an important role in the detoxification of chemical carcinogens. The induction of these detoxifying enzymes by a variety of agents occurs at the transcriptional level and is regulated
J C Lee et al.
Nature, 372(6508), 739-746 (1994-12-22)
Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds was identified as a pair of closely related mitogen-activated
Sarah Lockhead et al.
Cell reports, 32(2), 107901-107901 (2020-07-16)
Protein synthesis inhibitors (e.g., cycloheximide) block mitotic entry, suggesting that cell cycle progression requires protein synthesis until right before mitosis. However, cycloheximide is also known to activate p38 mitogen-activated protein kinase (MAPK), which can delay mitotic entry through a G2/M
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