539209

Protein Arginine N-Methyltransferase Inhibitor, AMI-1

The Protein Arginine N-Methyltransferase Inhibitor, AMI-1 controls the biological activity of Protein Arginine N-Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 동의어(들): Protein Arginine N-Methyltransferase Inhibitor, AMI-1, PRMT Inhibitor I
• 실험식(Hill 표기법): C₂₁H₁₂N₂Na₄O₉S₂
• Molecular Weight: 592.42
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic); protect from light
• solubility: water: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C

설명

일반 설명

A cell-permeable, symmetrical sulfonated urea compound that acts as a potent, specific and non-AdoMet (S-adenosyl-L-methionine, SAM)-competitive inhibitor of protein arginine N-methyltransferases (PRMTs; IC₅₀ = 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p) with minimal effect on lysine methyltransferases. Inhibits nuclear receptor reporter gene activation in MCF-7 cells, and HIV-1 RT polymerase (IC₅₀ = 5 µM).

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
Protein arginine N-methyltransferases (PRMTs)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 8.81 µM for PRMT1 and 3.03 for yeast-RMT1p

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

재구성

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

기타 정보

Cheng, D., et al. 2004. J. Biol. Chem.279, 23892.
Skillman, A.G., et al. 2002. Bioorg. Chem.30, 443.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable