524748

PDE4D Inhibitor, GEBR-7b

The PDE4D Inhibitor, GEBR-7b controls the biological activity of PDE4D. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• 동의어(들): PDE4D Inhibitor, GEBR-7b, GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
• 실험식(Hill 표기법): C₂₁H₃₀N₂O₅
• CAS Number: 1349848-90-3
• Molecular Weight: 390.47
• MDL number: MFCD28053503
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: semisolid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: pale yellow
• solubility: DMSO: 100 mg/mL, clear, colorless
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: COC1=C(OC2CCCC2)C=C(/C([H])=N/OCC(N3CC(C)OC(C)C3)=O)C=C1
• InChI key: JEXHQZPMUKFOIV-SSDVNMTOSA-N

설명

일반 설명

A cell permeable, potent, and selective oxime PDE4D inhibitor (IC₅₀ = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Aβ levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.

포장

Packaged under inert gas

경고

Toxicity: Standard Handling (A)

기타 정보

Bruno, O., et al. 2011. Br. J. Pharmacol.in press.
Bruno, O., et al. 2009. J. Med. Chem.52, 6546.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable